| Descriptor English: | Receptor Tyrosine Kinase-like Orphan Receptors | ||||||
| Descriptor Spanish: |
Receptores Huérfanos Similares al Receptor Tirosina Quinasa
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| Descriptor Portuguese: | Receptores Órfãos Semelhantes a Receptor Tirosina Quinase | ||||||
| Descriptor French: | Récepteurs orphelins de type récepteur à tyrosine kinase | ||||||
| Entry term(s): |
Kinase, ROR2 Tyrosine NTRKR Receptors Neurotrophic Tyrosine Kinase, Receptor related Proteins Neurotrophic Tyrosine Kinase, Receptor-related Proteins ROR Tyrosine Kinase Receptors ROR1 Tyrosine Kinase ROR2 Tyrosine Kinase Receptor Tyrosine Kinase like Orphan Receptor 1 Receptor Tyrosine Kinase like Orphan Receptor 2 Receptor Tyrosine Kinase like Orphan Receptors Receptor Tyrosine Kinase-like Orphan Receptor Receptor Tyrosine Kinase-like Orphan Receptor 1 Receptor Tyrosine Kinase-like Orphan Receptor 2 Tyrosine Kinase, ROR1 |
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| Tree number(s): |
D08.811.913.696.620.682.725.400.093 D12.776.476.568.400.093 D12.776.543.750.630.233 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D057050 | ||||||
| Scope note: | A family of cell surface receptors that were originally identified by their structural homology to neurotropic TYROSINE KINASES and referred to as orphan receptors because the associated ligand and signaling pathways were unknown. Evidence for the functionality of these proteins has been established by experiments showing that disruption of the orphan receptor genes results in developmental defects. |
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| Annotation: | do not confuse with ORPHAN NUCLEAR RECEPTORS |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.10.1 | ||||||
| Previous Indexing: |
Protein-Tyrosine Kinase (1983-1993) Receptor Protein-Tyrosine Kinases (1994-2009) |
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| Public MeSH Note: | 2010 |
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| History Note: | 2010 |
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| DeCS ID: | 53614 | ||||||
| Unique ID: | D057050 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2010/01/01 | ||||||
| Date of Entry: | 2009/07/06 | ||||||
| Revision Date: | 2016/05/31 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Receptor Tyrosine Kinase-like Orphan Receptors
- Preferred
Receptor Tyrosine Kinase-like Orphan Receptor 2
- Narrower
Receptor Tyrosine Kinase-like Orphan Receptor 1
- Narrower
| Concept UI |
M0533994 |
| Scope note | A family of cell surface receptors that were originally identified by their structural homology to neurotropic TYROSINE KINASES and referred to as orphan receptors because the associated ligand and signaling pathways were unknown. Evidence for the functionality of these proteins has been established by experiments showing that disruption of the orphan receptor genes results in developmental defects. |
| Preferred term | Receptor Tyrosine Kinase-like Orphan Receptors |
| Entry term(s) |
NTRKR Receptors Neurotrophic Tyrosine Kinase, Receptor related Proteins Neurotrophic Tyrosine Kinase, Receptor-related Proteins ROR Tyrosine Kinase Receptors Receptor Tyrosine Kinase like Orphan Receptors Receptor Tyrosine Kinase-like Orphan Receptor |
| Concept UI |
M0533996 |
| Preferred term | Receptor Tyrosine Kinase-like Orphan Receptor 2 |
| Entry term(s) |
Kinase, ROR2 Tyrosine ROR2 Tyrosine Kinase Receptor Tyrosine Kinase like Orphan Receptor 2 |
| Concept UI |
M0533995 |
| Preferred term | Receptor Tyrosine Kinase-like Orphan Receptor 1 |
| Entry term(s) |
ROR1 Tyrosine Kinase Receptor Tyrosine Kinase like Orphan Receptor 1 Tyrosine Kinase, ROR1 |
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