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Descriptor English: Proto-Oncogene Proteins c-kit
Descriptor Spanish: Proteínas Proto-Oncogénicas c-kit
Descriptor proteínas protooncogénicas c-kit
Entry term(s) antígenos CD117
p145(c-kit)
proteína c-kit
proteína proto-oncogénica kit
proteína protooncogénica kit
proteínas de protooncogén c-kit
proteínas del protooncogén c-kit
receptor c-kit
receptor del factor de células madre
Scope note: Receptor proteína tirosina cinasa específico del FACTOR DE CÉLULA MADRE. Esta interacción es crucial para el desarrollo de las células madre hematopoyéticas, gonadales y pigmentadas. Las mutaciones genéticas que desestructuran la expresión de la PROTEINAS PROTOONCOGÉNICAS C-KIT se asocian a PIEBALDISMO, mientras que la hiperexpresión o la activacion constitutiva de la proteína tirosina cinasa c-kit se asocia con la génesis tumoral.
Descriptor Portuguese: Proteínas Proto-Oncogênicas c-kit
Descriptor French: Protéines proto-oncogènes c-kit
Entry term(s): Antigens, CD117
CD117 Antigen
CD117 Antigens
Proto Oncogene Protein c kit
Proto Oncogene Protein kit
Proto Oncogene Proteins c kit
Proto-Oncogene Protein c-kit
Proto-Oncogene Protein kit
Proto-Oncogene Protein, kit
Receptor, Stem Cell Factor
SCF Receptor
Stem Cell Factor Receptor
c kit Protein
c kit Receptor
c-kit Protein
c-kit Receptor
c-kit, Proto-Oncogene Protein
c-kit, Proto-Oncogene Proteins
c-kit, p145
kit Proto Oncogene Protein
kit Proto-Oncogene Protein
p145 c kit
p145 c-kit
p145(c-kit)
p145c kit
p145c-kit
Tree number(s): D08.811.913.696.620.682.725.400.050
D12.776.476.568.400.050
D12.776.543.750.630.124
D12.776.543.750.705.852.150.100
D12.776.543.750.750.400.200.170
D12.776.624.664.700.183
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019009
Scope note: A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.10.1
Previous Indexing: Proto-Oncogene Proteins (1989-1995)
Receptor Protein-Tyrosine Kinase (1994-1995)
Receptors, Colony-Stimulating Factor (1991-1995)
Public MeSH Note: 2000; see PROTO-ONCOGENE PROTEINS C-KIT 1999-1996; PROTO-ONCOGENE PROTEIN KIT (now PROTO-ONCOGENE PROTEIN C-KIT) was indexed under RECEPTOR PROTEIN-TYROSINE KINASE 1994-1995; RECEPTORS, COLONY-STIMULATING FACTOR 1991-1995; & PROTO-ONCOGENE PROTEINS 1989-1995
History Note: 2000(1996); use PROTO-ONCOGENE PROTEIN c-KIT (NM) 1989-1995
Related: Piebaldism MeSH
DeCS ID: 32639
Unique ID: D019009
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1996/01/01
Date of Entry: 1995/05/26
Revision Date: 2017/05/24
Proto-Oncogene Proteins c-kit - Preferred
Concept UI M0028387
Scope note A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
Preferred term Proto-Oncogene Proteins c-kit
Entry term(s) Antigens, CD117
CD117 Antigen
CD117 Antigens
Proto Oncogene Protein c kit
Proto Oncogene Protein kit
Proto Oncogene Proteins c kit
Proto-Oncogene Protein c-kit
Proto-Oncogene Protein kit
Proto-Oncogene Protein, kit
Receptor, Stem Cell Factor
SCF Receptor
Stem Cell Factor Receptor
c kit Protein
c kit Receptor
c-kit Protein
c-kit Receptor
c-kit, Proto-Oncogene Protein
c-kit, Proto-Oncogene Proteins
c-kit, p145
kit Proto Oncogene Protein
kit Proto-Oncogene Protein
p145 c kit
p145 c-kit
p145(c-kit)
p145c kit
p145c-kit



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