| Descriptor English: | Anaplastic Lymphoma Kinase | ||||||
| Descriptor Spanish: |
Quinasa de Linfoma Anaplásico
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| Descriptor Portuguese: | Quinase do Linfoma Anaplásico | ||||||
| Descriptor French: | Kinase du lymphome anaplasique | ||||||
| Entry term(s): |
ALK Kinase ALK Tyrosine Kinase Receptor Anaplastic Lymphoma Receptor Tyrosine Kinase CD246 Antigen NPM-ALK Nucleophosmin Anaplastic Lymphoma Kinase Nucleophosmin-Anaplastic Lymphoma Kinase |
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| Tree number(s): |
D08.811.913.696.620.682.725.400.002 D12.776.476.568.400.002 D12.776.543.750.630.002 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000077548 | ||||||
| Scope note: | A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA. |
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| Allowable Qualifiers: |
AD administration & dosage AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CH chemistry CL classification DE drug effects DF deficiency GE genetics HI history IM immunology IP isolation & purification ME metabolism PH physiology RE radiation effects TU therapeutic use UL ultrastructure |
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| Registry Number: | EC 2.7.10.1 | ||||||
| Public MeSH Note: | 2019; ANAPLASTIC LYMPHOMA KINASE was indexed under RECEPTOR PROTEIN-TYROSINE KINASES 2012-2018; and under PROTEIN-TYROSINE KINASES 1994-2011 |
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| History Note: | 2019 (1994) |
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| DeCS ID: | 57673 | ||||||
| Unique ID: | D000077548 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2019/01/01 | ||||||
| Date of Entry: | 2018/07/09 | ||||||
| Revision Date: | 2018/06/19 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Anaplastic Lymphoma Kinase
- Preferred
| Concept UI |
M0228330 |
| Scope note | A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA. |
| Preferred term | Anaplastic Lymphoma Kinase |
| Entry term(s) |
ALK Kinase ALK Tyrosine Kinase Receptor Anaplastic Lymphoma Receptor Tyrosine Kinase CD246 Antigen NPM-ALK Nucleophosmin Anaplastic Lymphoma Kinase Nucleophosmin-Anaplastic Lymphoma Kinase |
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