| Descriptor English: | c-Mer Tyrosine Kinase | ||||||
| Descriptor Spanish: |
Tirosina Quinasa c-Mer
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| Descriptor Portuguese: | c-Mer Tirosina Quinase | ||||||
| Descriptor French: | c-Mer Tyrosine kinase | ||||||
| Entry term(s): |
Kinase, c-Mer Tyrosine MERTK Tyrosine Kinase, c-Mer c Mer Proto Oncogene Tyrosine Kinase c Mer Tyrosine Kinase c-Mer Proto-Oncogene Tyrosine Kinase |
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| Tree number(s): |
D08.811.913.696.620.682.725.400.003 D12.776.476.568.400.003 D12.776.543.750.630.003 D12.776.624.664.700.037 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000076202 | ||||||
| Scope note: | A receptor tyrosine kinase that transduces signals from EXTRACELLULAR MATRIX to the CYTOPLASM by binding ligands such as GALECTIN 3. It regulates many physiologic processes that include cell survival, migration, differentiation, and PHAGOCYTOSIS of apoptotic cells and ROD PHOTORECEPTORS in the RETINAL PIGMENT EPITHELIUM. Mutations in the MERTK gene are associated with type 38 RETINITIS PIGMENTOSA; it also plays a critical role as an inhibitor of TOLL-LIKE RECEPTORS signaling. |
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| Allowable Qualifiers: |
AD administration & dosage AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CH chemistry CL classification DE drug effects DF deficiency GE genetics HI history IM immunology IP isolation & purification ME metabolism PH physiology RE radiation effects TU therapeutic use UL ultrastructure |
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| Registry Number: | EC 2.7.10.1 | ||||||
| Previous Indexing: |
Proto-Oncogene Proteins (1999-2017) Receptor Protein-Tyrosine Kinases (1999-2017) |
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| Public MeSH Note: | 2018 |
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| History Note: | 2018 |
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| DeCS ID: | 57034 | ||||||
| Unique ID: | D000076202 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/06/29 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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c-Mer Tyrosine Kinase
- Preferred
| Concept UI |
M000632438 |
| Scope note | A receptor tyrosine kinase that transduces signals from EXTRACELLULAR MATRIX to the CYTOPLASM by binding ligands such as GALECTIN 3. It regulates many physiologic processes that include cell survival, migration, differentiation, and PHAGOCYTOSIS of apoptotic cells and ROD PHOTORECEPTORS in the RETINAL PIGMENT EPITHELIUM. Mutations in the MERTK gene are associated with type 38 RETINITIS PIGMENTOSA; it also plays a critical role as an inhibitor of TOLL-LIKE RECEPTORS signaling. |
| Preferred term | c-Mer Tyrosine Kinase |
| Entry term(s) |
Kinase, c-Mer Tyrosine MERTK Tyrosine Kinase, c-Mer c Mer Proto Oncogene Tyrosine Kinase c Mer Tyrosine Kinase c-Mer Proto-Oncogene Tyrosine Kinase |
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