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Descriptor English: Cytochrome P-450 CYP2C8
Descriptor Spanish: Citocromo P-450 CYP2C8
Descriptor citocromo P-450 CYP2C8
Scope note: Citocromo P-450 hidroxilasa microsómica del hígado que oxida un amplio espectro de sustratos como ESTEROIDES, ÁCIDOS GRASOS y XENOBIÓTICOS. Entre los ejemplos de sustratos farmacéuticos de la CYP2C8 están el PACLITAXEL, la torsemida y la AMODIAQUINA.
Descriptor Portuguese: Citocromo P-450 CYP2C8
Descriptor French: Cytochrome P-450 CYP2C8
Entry term(s): 4-Hydroxylase, S-Mephenytoin
CYP2C8
CYP2C8, Cytochrome P-450
CYPIIC8
Cytochrome P 450 CYP2C8
Cytochrome P450 MP 20
Cytochrome P450 MP-20
Cytochrome P450, Family 2, Subfamily C, Polypeptide 8
P-450 CYP2C8, Cytochrome
P450 MP-20, Cytochrome
S Mephenytoin 4 Hydroxylase
S-Mephenytoin 4-Hydroxylase
Tree number(s): D08.244.453.005.590
D08.244.453.491.368
D08.811.682.690.708.170.010.590
D08.811.682.690.708.170.450.360
D12.776.422.220.453.010.590
D12.776.422.220.453.491.360
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D065727
Scope note: A liver microsomal cytochrome P450 hydroxylase that oxidizes a broad spectrum of substrates including STEROIDS, FATTY ACIDS, and XENOBIOTICS. Examples of pharmaceutical substrates for CYP2C8 include; PACLITAXOL; torsemide; and; AMODIAQUINE
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Cytochrome P-450 CYP2C8 Inhibitors
Registry Number: EC 1.14.14.1
Previous Indexing: Aryl Hydrocarbon Hydroxylases (2002-2014)
Public MeSH Note: 2015
History Note: 2015
DeCS ID: 55607
Unique ID: D065727
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2015/01/01
Date of Entry: 2014/06/26
Revision Date: 2016/05/27
Cytochrome P-450 CYP2C8 - Preferred
Concept UI M0590595
Scope note A liver microsomal cytochrome P450 hydroxylase that oxidizes a broad spectrum of substrates including STEROIDS, FATTY ACIDS, and XENOBIOTICS. Examples of pharmaceutical substrates for CYP2C8 include; PACLITAXOL; torsemide; and; AMODIAQUINE
Preferred term Cytochrome P-450 CYP2C8
Entry term(s) 4-Hydroxylase, S-Mephenytoin
CYP2C8
CYP2C8, Cytochrome P-450
CYPIIC8
Cytochrome P 450 CYP2C8
Cytochrome P450 MP 20
Cytochrome P450 MP-20
Cytochrome P450, Family 2, Subfamily C, Polypeptide 8
P-450 CYP2C8, Cytochrome
P450 MP-20, Cytochrome
S Mephenytoin 4 Hydroxylase
S-Mephenytoin 4-Hydroxylase



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