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Descriptor English: Nedd4 Ubiquitin Protein Ligases
Descriptor Spanish: Ubiquitina-Proteína Ligasas Nedd4
Descriptor ubiquitina-proteína ligasas Nedd4
Entry term(s) ligasa 4 regulada por el desarrollo y expresada por las células precursoras neuronales
proteínas Nedd4
Scope note: Ubiquitina-ligasas E3 que constan de cuatro DOMINIOS WW. Mediante sus dominios HECT del extremo C, captan la UBIQUITINA, en forma de tioéster, de las ENZIMAS DE CONJUGACIÓN DE LA UBIQUITINA E2 y la transfieren específicamente al residuo de LISINA número 63 (Lys-63) de las proteínas sobre las que actúan. Las dianas NEDD4 incluyen muchas proteínas y receptores con importantes funciones para el crecimiento celular y la homeostasis, como los receptores VEGFR-2, el RECEPTOR TIPO 1 DE FACTOR DE CRECIMIENTO DE FIBROBLASTOS y el RECEPTOR ERBB-4. Juegan un papel crítico en la internalización de estos receptores y en su degradación por los LISOSOMAS; así mismo, también forman parte del complejo ESCRT en la LIBERACIÓN DE VIRUS.
Descriptor Portuguese: Ubiquitina-Proteína Ligases Nedd4
Descriptor French: Ubiquitine protéine ligases NEDD4
Entry term(s): Nedd4 Proteins
Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 Ligase
Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase
Tree number(s): D05.500.199.500
D08.811.464.938.750.257
D12.776.543.990.493.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000075702
Scope note: E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.3.2.26
Public MeSH Note: 2018; NEDD4 UBIQUITIN PROTEIN LIGASES was indexed under UBIQUITIN-PROTEIN LIGASES and ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT 2005-2017; under LIGASES 1996-2004; and under CALCIUM-BINDING PROTEINS 1996-2003
History Note: 2018 (1996)
DeCS ID: 56981
Unique ID: D000075702
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
Nedd4 Ubiquitin Protein Ligases - Preferred
Concept UI M0453577
Scope note E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.
Preferred term Nedd4 Ubiquitin Protein Ligases
Entry term(s) Nedd4 Proteins
Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 Ligase
Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase



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