| Descriptor English: | Cytokine TWEAK | ||||||
| Descriptor Spanish: |
Citocina TWEAK
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| Descriptor Portuguese: | Citocina TWEAK | ||||||
| Descriptor French: | Cytokine TWEAK | ||||||
| Entry term(s): |
Apo3 Ligand Cytokine, TWEAK Ligand, Apo3 TNF Related Weak Inducer of Apoptosis TNF-Related Weak Inducer of Apoptosis TWEAK Cytokine TWEAK, Cytokine Tumor Necrosis Factor Ligand Superfamily Member 12 |
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| Tree number(s): |
D12.644.276.374.750.155 D12.776.467.374.750.155 D23.529.374.750.155 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000074049 | ||||||
| Scope note: | A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Tumor Necrosis Factors (2006-2017) |
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| Public MeSH Note: | 2018 |
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| History Note: | 2018 |
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| DeCS ID: | 57053 | ||||||
| Unique ID: | D000074049 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/02/24 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors
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Cytokine TWEAK
- Preferred
| Concept UI |
M000625319 |
| Scope note | A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION. |
| Preferred term | Cytokine TWEAK |
| Entry term(s) |
Apo3 Ligand Cytokine, TWEAK Ligand, Apo3 TNF Related Weak Inducer of Apoptosis TNF-Related Weak Inducer of Apoptosis TWEAK Cytokine TWEAK, Cytokine Tumor Necrosis Factor Ligand Superfamily Member 12 |
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