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Descriptor English: Lymphotoxin alpha1, beta2 Heterotrimer
Descriptor Spanish: Heterotrímero de Linfotoxina alfa1 y beta2
Descriptor heterotrímero de linfotoxina alfa1 y beta2
Scope note: Complejo heterotrimérico que consta de una molécula de LINFOTOXINA ALFA y dos moléculas de LINFOTOXINA BETA. Está anclado en la superficie celular por unos dominios transmembranarios del componente linfotoxina beta y tiene especificidad por el RECEPTOR DE LINFOTOXINA BETA. El heterotrímero de linfotoxina alfa1 y beta2 desempeña un papel en la regulación de la ORGANOGÉNESIS linfoide y en la diferenciación de ciertos subgrupos de CÉLULAS CITOLÍTICAS NATURALES.
Descriptor Portuguese: Heterotrímero de Linfotoxina alfa1 e beta2
Descriptor French: Hétérotrimère de lymphotoxines alpha1 bêta2
Entry term(s): Heterotrimer, Lymphotoxin alphabeta
Lymphotoxin alpha1beta2
Lymphotoxin alphabeta
Lymphotoxin alphabeta Heterotrimer
alpha1beta2, Lymphotoxin
alphabeta Heterotrimer, Lymphotoxin
Tree number(s): D12.644.276.374.750.505
D12.776.467.374.750.505
D23.529.374.750.505
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053361
Scope note: A heterotrimer complex consisting of one molecule of LYMPHOTOXIN-ALPHA and two molecules of the LYMPHOTOXIN-BETA. It is anchored to the cell surface via the transmembrane domains of the lymphotoxin-beta component and has specificity for the LYMPHOTOXIN BETA RECEPTOR. The lymphotoxin alpha1, beta2 heterotrimer plays a role in regulating lymphoid ORGANOGENESIS and the differentiation of certain subsets of NATURAL KILLER CELLS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Tumor Necrosis Factors (1974-2006)
Public MeSH Note: 2007
History Note: 2007
DeCS ID: 52294
Unique ID: D053361
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2015/06/23
Lymphotoxin alpha1, beta2 Heterotrimer - Preferred
Concept UI M0492829
Scope note A heterotrimer complex consisting of one molecule of LYMPHOTOXIN-ALPHA and two molecules of the LYMPHOTOXIN-BETA. It is anchored to the cell surface via the transmembrane domains of the lymphotoxin-beta component and has specificity for the LYMPHOTOXIN BETA RECEPTOR. The lymphotoxin alpha1, beta2 heterotrimer plays a role in regulating lymphoid ORGANOGENESIS and the differentiation of certain subsets of NATURAL KILLER CELLS.
Preferred term Lymphotoxin alpha1, beta2 Heterotrimer
Entry term(s) Heterotrimer, Lymphotoxin alphabeta
Lymphotoxin alpha1beta2
Lymphotoxin alphabeta
Lymphotoxin alphabeta Heterotrimer
alpha1beta2, Lymphotoxin
alphabeta Heterotrimer, Lymphotoxin



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