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Descriptor English: Amanitins
Descriptor Spanish: Amanitinas
Descriptor amanitinas
Entry term(s) amanitina
Scope note: Péptidos cíclicos extraídos de los carpóforos de varias especies de hongos. Son potentes inhibidores de las ARN polimerasas en la mayoría de las especies eucariotas, y bloquean la producción de ARNm y la síntesis proteica. Estos péptidos son importantes en el estudio de la transcripción. La alfa-amanitina es la principal toxina de la especie Amanita phalloides, que es venenosa si la ingieren los humanos o animales.
Descriptor Portuguese: Amanitinas
Descriptor French: Amanitines
Entry term(s): Amanitin
Tree number(s): D04.345.566.050
D12.644.456.050
D12.644.641.050
D23.946.587.175
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000546
Scope note: Cyclic peptides extracted from carpophores of various mushroom species. They are potent inhibitors of RNA polymerases in most eukaryotic species, blocking the production of mRNA and protein synthesis. These peptides are important in the study of transcription. Alpha-amanitin is the main toxin from the species Amanitia phalloides, poisonous if ingested by humans or animals.
Annotation: /antag permitted but consider also ANTITOXINS
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Enzyme Inhibitors
Poisons
Nucleic Acid Synthesis Inhibitors
Previous Indexing: Mycotoxins (1974)
Oligopeptides (1974)
Peptides, Cyclic (1974)
Public MeSH Note: 75
History Note: 75
DeCS ID: 546
Unique ID: D000546
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1975/09/01
Date of Entry: 1974/11/11
Revision Date: 2020/05/27
Amanitins - Preferred
Concept UI M0000846
Scope note Cyclic peptides extracted from carpophores of various mushroom species. They are potent inhibitors of RNA polymerases in most eukaryotic species, blocking the production of mRNA and protein synthesis. These peptides are important in the study of transcription. Alpha-amanitin is the main toxin from the species Amanitia phalloides, poisonous if ingested by humans or animals.
Preferred term Amanitins
Entry term(s) Amanitin



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