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Descriptor English: Neprilysin
Descriptor Spanish: Neprilisina
Descriptor Portuguese: Neprilisina
Descriptor French: Néprilysine
Entry term(s): Antigen, CD10
Antigens, CD10
Antigens, Leukemia, Common Acute Lymphoblastic
Atriopeptidase
CALLA Antigen
CD10 Antigen
CD10 Antigens
Carboxypeptidase, Enkephalin Dipeptidyl
Common Acute Lymphoblastic Leukemia Antigens
Dipeptidyl Carboxypeptidase, Enkephalin
Endopeptidase 24.11
Endopeptidase 24.11, Neutral
Endopeptidase, Neutral
Endopeptidase-24.11
Enkephalin Dipeptidyl Carboxypeptidase
Enkephalinase
Enkephalinase 24.11
Enkephalinase-24.11
Enzyme, YGG-Forming
Kidney Brush Border Neutral Proteinase
Kidney-Brush-Border Neutral Proteinase
Membrane Metallo Endopeptidase
Membrane Metallo-Endopeptidase
Metallo-Endopeptidase, Membrane
Metalloendopeptidase, Thermolysin-Like
Neutral Endopeptidase
Neutral Endopeptidase 24.11
Neutral Proteinase, Kidney-Brush-Border
Thermolysin Like Metalloendopeptidase
Thermolysin-Like Metalloendopeptidase
YGG Forming Enzyme
YGG-Forming Enzyme
Tree number(s): D08.811.277.656.300.480.600
D08.811.277.656.675.374.600
D23.050.285.550
D23.101.140.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015260
Scope note: Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
Annotation:
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.24.11
Previous Indexing: Metalloproteinases (1987-1988)
Peptide Peptidohydrolases (1966-1987)
Public MeSH Note: 1997; was MEMBRANE METALLO-ENDOPEPTIDASE 1989-96; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS was indexed under ANTIGENS, NEOPLASM & ANTIGENS, DIFFERENTIATION 1983-92; for CALLA ANTIGEN see CALLA 1993-2002
Online Note: use NEPRILYSIN (NM) to search COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS 1983-92
History Note: 1997; was MEMBRANE METALLO-ENDOPEPTIDASE 1989-96; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS was COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS (NM) 1983-92
DeCS ID: 23757
Unique ID: D015260
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1989/01/01
Date of Entry: 1988/05/18
Revision Date: 2017/05/24
Neprilysin - Preferred
Concept UI M0023500
Scope note Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
Preferred term Neprilysin
Entry term(s) Antigen, CD10
Antigens, CD10
Antigens, Leukemia, Common Acute Lymphoblastic
Atriopeptidase
CALLA Antigen
CD10 Antigen
CD10 Antigens
Carboxypeptidase, Enkephalin Dipeptidyl
Common Acute Lymphoblastic Leukemia Antigens
Dipeptidyl Carboxypeptidase, Enkephalin
Endopeptidase 24.11
Endopeptidase 24.11, Neutral
Endopeptidase, Neutral
Endopeptidase-24.11
Enkephalin Dipeptidyl Carboxypeptidase
Enkephalinase
Enkephalinase 24.11
Enkephalinase-24.11
Enzyme, YGG-Forming
Kidney Brush Border Neutral Proteinase
Kidney-Brush-Border Neutral Proteinase
Membrane Metallo Endopeptidase
Membrane Metallo-Endopeptidase
Metallo-Endopeptidase, Membrane
Metalloendopeptidase, Thermolysin-Like
Neutral Endopeptidase
Neutral Endopeptidase 24.11
Neutral Proteinase, Kidney-Brush-Border
Thermolysin Like Metalloendopeptidase
Thermolysin-Like Metalloendopeptidase
YGG Forming Enzyme
YGG-Forming Enzyme



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