PHENOMENA AND PROCESSES Chemical Phenomena [G02] Chemical Phenomena Biochemical Phenomena [G02.111] Biochemical Phenomena Acid-Base Equilibrium [G02.111.007] Acid-Base Equilibrium Acylation [G02.111.012] Acylation Aerobiosis [G02.111.017] Aerobiosis Agglutination [G02.111.026] Agglutination Alkylation [G02.111.035] Alkylation Allosteric Regulation [G02.111.044] Allosteric Regulation Amination [G02.111.053] Amination Anaerobiosis [G02.111.062] Anaerobiosis Autotrophic Processes [G02.111.071] Autotrophic Processes Base Composition [G02.111.080] Base Composition Binding, Competitive [G02.111.084] Binding, Competitive Biocatalysis [G02.111.086] Biocatalysis Biomineralization [G02.111.092] Biomineralization Biosynthetic Pathways [G02.111.098] Biosynthetic Pathways Biotinylation [G02.111.109] Biotinylation Body Composition [G02.111.130] Body Composition Brain Chemistry [G02.111.150] Brain Chemistry Carbohydrate Metabolism [G02.111.158] Carbohydrate Metabolism Citric Acid Cycle [G02.111.165] Citric Acid Cycle Cyclization [G02.111.180] Cyclization Dealkylation [G02.111.188] Dealkylation Deamination [G02.111.192] Deamination Decarboxylation [G02.111.195] Decarboxylation DNA Cleavage [G02.111.210] DNA Cleavage DNA Methylation [G02.111.218] DNA Methylation DNA Repair [G02.111.222] DNA Repair DNA Replication [G02.111.225] DNA Replication Down-Regulation [G02.111.240] Down-Regulation Electron Transport [G02.111.248] Electron Transport Energy Transfer [G02.111.255] Energy Transfer Enzyme Activation [G02.111.263] Enzyme Activation Esterification [G02.111.270] Esterification Halogenation [G02.111.323] Halogenation Heterotrophic Processes [G02.111.375] Heterotrophic Processes Hydrogenation [G02.111.380] Hydrogenation Hydroxylation [G02.111.385] Hydroxylation Kinetics [G02.111.490] Kinetics Lipid Peroxidation [G02.111.515] Lipid Peroxidation Lipogenesis [G02.111.528] Lipogenesis Lipolysis [G02.111.534] Lipolysis Lipoylation [G02.111.540] Lipoylation Melanogenesis [G02.111.545] Melanogenesis Membrane Fluidity [G02.111.550] Membrane Fluidity Molecular Mimicry [G02.111.560] Molecular Mimicry Molecular Structure [G02.111.570] Molecular Structure Nitrogen Cycle [G02.111.587] Nitrogen Cycle Nitrosation [G02.111.595] Nitrosation Nucleic Acid Denaturation [G02.111.603] Nucleic Acid Denaturation Nucleic Acid Hybridization [G02.111.611] Nucleic Acid Hybridization Nucleic Acid Renaturation [G02.111.619] Nucleic Acid Renaturation Osmoregulation [G02.111.635] Osmoregulation Osmosis [G02.111.655] Osmosis Peptide Biosynthesis [G02.111.660] Peptide Biosynthesis Phosphorylation [G02.111.665] Phosphorylation Phototrophic Processes [G02.111.669] Phototrophic Processes Prenylation [G02.111.672] Prenylation Protein Aggregation, Pathological [G02.111.675] Protein Aggregation, Pathological Protein Binding [G02.111.679] Protein Binding Protein Folding [G02.111.688] Protein Folding Protein Modification, Translational [G02.111.691] Protein Modification, Translational Protein Multimerization [G02.111.694] Protein Multimerization Protein Stability [G02.111.700] Protein Stability Proteolysis [G02.111.720] Proteolysis Proteostasis [G02.111.730] Proteostasis RNA Cleavage [G02.111.740] RNA Cleavage RNA Folding [G02.111.750] RNA Folding RNA Processing, Post-Transcriptional [G02.111.760] RNA Processing, Post-Transcriptional RNA Replication [G02.111.770] RNA Replication RNA Stability [G02.111.780] RNA Stability Sequence Homology [G02.111.810] Sequence Homology Signal Transduction [G02.111.820] Signal Transduction Structure-Activity Relationship [G02.111.830] Structure-Activity Relationship Substrate Cycling [G02.111.833] Substrate Cycling Substrate Specificity [G02.111.835] Substrate Specificity Transcription, Genetic [G02.111.873] Transcription, Genetic Up-Regulation [G02.111.905] Up-Regulation PHENOMENA AND PROCESSES Metabolism [G03] Metabolism Energy Metabolism [G03.295] Energy Metabolism Basal Metabolism [G03.295.154] Basal Metabolism Citric Acid Cycle [G03.295.342] Citric Acid Cycle Glycolysis [G03.295.436] Glycolysis Metabolic Reprogramming [G03.295.484] Metabolic Reprogramming Oxidation-Reduction [G03.295.531] Oxidation-Reduction Oxidative Phosphorylation [G03.295.631] Oxidative Phosphorylation Pentose Phosphate Pathway [G03.295.693] Pentose Phosphate Pathway Photophosphorylation [G03.295.724] Photophosphorylation Proton-Motive Force [G03.295.770] Proton-Motive Force Substrate Cycling [G03.295.835] Substrate Cycling

Substrate Cycling - Preferred

Concept UI	M0023381
Scope note	A set of opposing, nonequilibrium reactions catalyzed by different enzymes which act simultaneously, with at least one of the reactions driven by ATP hydrolysis. The results of the cycle are that ATP energy is depleted, heat is produced and no net substrate-to-product conversion is achieved. Examples of substrate cycling are cycling of gluconeogenesis and glycolysis pathways and cycling of the triglycerides and fatty acid pathways. Rates of substrate cycling may be increased many-fold in association with hypermetabolic states resulting from severe burns, cold exposure, hyperthyroidism, or acute exercise.
Preferred term	Substrate Cycling
Entry term(s)	Cycling, Substrate Cyclings, Substrate Substrate Cyclings

Futile Cycles - Narrower

Concept UI	M0023382
Preferred term	Futile Cycles
Entry term(s)	Cycle, Futile Cycle, Futile Substrate Cycles, Futile Cycles, Futile Substrate Cycling, Futile Cycling, Futile Substrate Cyclings, Futile Cyclings, Futile Substrate Futile Cycle Futile Cycling Futile Cyclings Futile Substrate Cycle Futile Substrate Cycles Futile Substrate Cycling Futile Substrate Cyclings Substrate Cycle, Futile Substrate Cycles, Futile Substrate Cycling, Futile Substrate Cyclings, Futile