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Descriptor in English: Protein Aggregation, Pathological
Descriptor in Spanish: Agregación Patológica de Proteínas
Descriptor in Portuguese: Agregação Patológica de Proteínas
Descriptor in French: Agrégation pathologique de protéines
Entry term(s): Aggregation, Pathological Protein
Pathological Protein Aggregation
Tree number(s): C23.550.770
G02.111.675
Scope note: A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION, POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS.
Allowable Qualifiers: BL blood
CF cerebrospinal fluid
CI chemically induced
CL classification
CN congenital
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SU surgery
TH therapy
UR urine
VE veterinary
VI virology
History Note: 2015
See also the descriptors: Protein Aggregates MeSH
DeCS UI: 55596
Descriptor UI: D066263
Date Established: 2015/01/01
Date of Entry: 2014/06/26
Revision Date: 2016/06/17
Protein Aggregation, Pathological - Preferred
Concept UI M0593510
Scope note A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION, POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS.
Preferred term Protein Aggregation, Pathological
Entry term(s) Aggregation, Pathological Protein
Pathological Protein Aggregation



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