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Descriptor English: Protein Aggregation, Pathological
Descriptor Spanish: Agregación Patológica de Proteínas
Descriptor agregación patológica de proteínas
Entry term(s) agregación proteica patológica
Scope note: Fenómeno bioquímico en el que proteínas con alteraciones del plegamiento se agregan en el interior o en el exterior de las células. Está desencadenado por factores tales como una MUTACIÓN, modificaciones postraduccionales y estrés ambiental. Generalmente se asocia a ENFERMEDAD DE ALZHEIMER, ENFERMEDAD DE PARKINSON, ENFERMEDAD DE HUNTINGTON y DIABETES TIPO 2.
Descriptor Portuguese: Agregação Patológica de Proteínas
Descriptor French: Agrégation pathologique de protéines
Entry term(s): Aggregation, Pathological Protein
Pathological Protein Aggregation
Tree number(s): C23.550.770
G02.111.675
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D066263
Scope note: A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION; POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS.
Allowable Qualifiers: BL blood
CF cerebrospinal fluid
CI chemically induced
CL classification
CN congenital
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SU surgery
TH therapy
UR urine
VE veterinary
VI virology
Public MeSH Note: 2015
History Note: 2015
Related: Protein Aggregates MeSH
DeCS ID: 55596
Unique ID: D066263
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2015/01/01
Date of Entry: 2014/06/26
Revision Date: 2020/02/05
Protein Aggregation, Pathological - Preferred
Concept UI M0593510
Scope note A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION; POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS.
Preferred term Protein Aggregation, Pathological
Entry term(s) Aggregation, Pathological Protein
Pathological Protein Aggregation



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