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Descriptor English: Nucleic Acid Hybridization
Descriptor Spanish: Hibridación de Ácido Nucleico
Descriptor Portuguese: Hibridização de Ácido Nucleico
Descriptor French: Hybridation d'acides nucléiques
Entry term(s): Acid Hybridization, Nucleic
Acid Hybridizations, Nucleic
Genomic Hybridization
Genomic Hybridizations
Hybridization, Genomic
Hybridization, Nucleic Acid
Hybridizations, Genomic
Hybridizations, Nucleic Acid
Nucleic Acid Hybridizations
Tree number(s): E05.393.661
G02.111.611
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D009693
Scope note: Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
Annotation: IM general only; coord NIM with DNA or RNA or specific (IM); IN SITU HYBRIDIZATION & IN SITU HYBRIDIZATION, FLUORESCENCE are available
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
IM immunology
MT methods
PH physiology
RE radiation effects
Previous Indexing: DNA (1966-1970)
RNA (1966-1970)
Public MeSH Note: 72
History Note: 72(71)
Related: Blotting, Southern MeSH
DeCS ID: 9880
Unique ID: D009693
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1972/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/06/17
Nucleic Acid Hybridization - Preferred
Concept UI M0015052
Scope note Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
Preferred term Nucleic Acid Hybridization
Entry term(s) Acid Hybridization, Nucleic
Acid Hybridizations, Nucleic
Hybridization, Nucleic Acid
Hybridizations, Nucleic Acid
Nucleic Acid Hybridizations
Genomic Hybridization - Broader
Concept UI M0015053
Preferred term Genomic Hybridization
Entry term(s) Genomic Hybridizations
Hybridization, Genomic
Hybridizations, Genomic



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