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Descriptor English: Aprotinin
Descriptor Spanish: Aprotinina
Descriptor aprotinina
Entry term(s) inactivador de calicreína-tripsina
inhibidor de la tripsina de Kunitz pancreática
inhibidor de la tripsina pancreática bovina de Kunitz
inhibidor de la tripsina pancreática básica
inhibidor de la tripsina pancreática básica BPTI
inhibidor de la tripsina pancreática de Kunitz
inhibidor de tripsina básica pancreática
Scope note: Polipéptido monocatenario derivado de tejidos bovinos que consta de 58 residuos de aminoácidos. Es inhibidor de las enzimas proteolíticas como QUIMOTRIPSINA, CALICREÍNA, PLASMINA y TRIPSINA. Se utiliza en el tratamiento de la HEMORRAGIA asociada con elevaciones plasmáticas altas de plasmina. Se emplea también para reducir la pérdida de sangre y los requerimientos transfusionales en los pacientes en riesgo alto de pérdida sanguínea importante y después de cirugía a corazón abierto con CIRCULACIÓN EXTRACORPÓREA. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
Descriptor Portuguese: Aprotinina
Descriptor French: Aprotinine
Entry term(s): Antilysine
Inhibiteur trypsique pancréatique Kunitz
Tree number(s): D12.776.083
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007611
Scope note: A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AG agonistes
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Pharm Action: Hemostatics
Trypsin Inhibitors
Serine Proteinase Inhibitors
Registry Number: 9087-70-1
DeCS ID: 28294
Unique ID: D007611
NLM Classification: QU 143
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/01
Aprotinine - Preferred
Concept UI M0011905
Preferred term Aprotinine
Entry term(s) Inhibiteur trypsique pancréatique Kunitz
Antilysine - Narrower
Concept UI M0011907
Preferred term Antilysine



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