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Descriptor in English: Intrinsically Disordered Proteins
Descriptor in Spanish: Proteínas Intrínsecamente Desordenadas
Descriptor in Portuguese: Proteínas Intrinsicamente Desordenadas
Descriptor in French: Protéines intrinsèquement désordonnées
Entry term(s): Natively Unfolded Proteins
Unstructured Proteins
Tree number(s): D12.776.481
Scope note: Functional proteins that do not have unique, stable, folded, three-dimensional native structures or that possess non-ordered regions under physiological conditions. They are characterized by extraordinary structural flexibility and plasticity, which enable them to adopt different conformations in response to different stimuli or different interactions.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
History Note: 2014
See also the descriptors: Protein Folding MeSH
Protein Unfolding MeSH
DeCS UI: 55331
Descriptor UI: D064267
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Intrinsically Disordered Proteins - Preferred
Concept UI M0580703
Scope note Functional proteins that do not have unique, stable, folded, three-dimensional native structures or that possess non-ordered regions under physiological conditions. They are characterized by extraordinary structural flexibility and plasticity, which enable them to adopt different conformations in response to different stimuli or different interactions.
Preferred term Intrinsically Disordered Proteins
Entry term(s) Natively Unfolded Proteins
Unstructured Proteins



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