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Descriptor English: Intrinsically Disordered Proteins
Descriptor Spanish: Proteínas Intrínsecamente Desordenadas
Descriptor proteínas intrínsecamente desestructuradas
Entry term(s) proteína intrínsecamente desordenada
proteína nativamente desplegada
proteína no estructurada
Scope note: Proteínas funcionales que no poseen estructuras nativas tridimensionales, plegadas, estables y propias o que poseen regiones no ordenadas en condiciones fisiológicas. Se caracterizan por tener una extraordinaria flexibilidad y plasticidad estructural lo que posibilita que adopten distintas conformaciones en respuesta a diferentes estímulos o interacciones.
Descriptor Portuguese: Proteínas Intrinsicamente Desordenadas
Descriptor French: Protéines intrinsèquement désordonnées
Entry term(s): Disordered Protein, Intrinsically
Intrinsically Disordered Protein
Natively Unfolded Protein
Natively Unfolded Proteins
Protein, Intrinsically Disordered
Protein, Natively Unfolded
Protein, Unstructured
Unfolded Protein, Natively
Unstructured Protein
Unstructured Proteins
Tree number(s): D12.776.481
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D064267
Scope note: Functional proteins that do not have unique, stable, folded, three-dimensional native structures or that possess non-ordered regions under physiological conditions. They are characterized by extraordinary structural flexibility and plasticity, which enable them to adopt different conformations in response to different stimuli or different interactions.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2014
History Note: 2014
Related: Protein Folding MeSH
Protein Unfolding MeSH
DeCS ID: 55331
Unique ID: D064267
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 2020/06/29
Intrinsically Disordered Proteins - Preferred
Concept UI M0580703
Scope note Functional proteins that do not have unique, stable, folded, three-dimensional native structures or that possess non-ordered regions under physiological conditions. They are characterized by extraordinary structural flexibility and plasticity, which enable them to adopt different conformations in response to different stimuli or different interactions.
Preferred term Intrinsically Disordered Proteins
Entry term(s) Disordered Protein, Intrinsically
Intrinsically Disordered Protein
Natively Unfolded Protein
Natively Unfolded Proteins
Protein, Intrinsically Disordered
Protein, Natively Unfolded
Protein, Unstructured
Unfolded Protein, Natively
Unstructured Protein
Unstructured Proteins



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