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Descriptor in English: Huntingtin Protein
Descriptor in Spanish: Proteína Huntingtina
Descriptor in Portuguese: Proteína Huntingtina
Descriptor in French: Protéine huntingtine
Entry term(s): Huntington Disease Protein
IT15 Protein
Tree number(s): D12.776.441
Scope note: A protein that is highly expressed in the nervous system as well as other tissues; its size and structure vary due to polymorphisms. Expanded CAG TRINUCLEOTIDE REPEATS have been identified in the Huntingtin (HD) Gene of patients with HUNTINGTON DISEASE and are associated with abnormal PROTEIN AGGREGATES. Huntingtin interacts with proteins involved in a variety of gene expression and cellular processes; it is also essential for embryonic development.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
History Note: 2017
DeCS UI: 56634
Descriptor UI: D000071058
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/02/26
Huntingtin Protein - Preferred
Concept UI M000612972
Scope note A protein that is highly expressed in the nervous system as well as other tissues; its size and structure vary due to polymorphisms. Expanded CAG TRINUCLEOTIDE REPEATS have been identified in the Huntingtin (HD) Gene of patients with HUNTINGTON DISEASE and are associated with abnormal PROTEIN AGGREGATES. Huntingtin interacts with proteins involved in a variety of gene expression and cellular processes; it is also essential for embryonic development.
Preferred term Huntingtin Protein
Entry term(s) Huntington Disease Protein
IT15 Protein



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