| Descriptor English: | Focal Adhesion Kinase 1 | ||||||
| Descriptor Spanish: |
Quinasa 1 de Adhesión Focal
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| Descriptor Portuguese: | Quinase 1 de Adesão Focal | ||||||
| Descriptor French: | Focal adhesion kinase 1 | ||||||
| Entry term(s): |
Endogenous Substrate pp120 Focal Adhesion Associated Protein Tyrosine Kinase pp125FAK Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK Protein Tyrosine Kinase 2 p125FAK Protein |
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| Tree number(s): |
D08.811.913.696.620.682.725.049.500 D12.776.476.568.049.500 D12.776.744.493 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D051417 | ||||||
| Scope note: | A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.10.2 | ||||||
| Public MeSH Note: | 2006; ENDOGENOUS SUBSTRATE PP120, FOCAL ADHESION-ASSOCIATED, PROTEIN-TYROSINE KINASE PP125FAK, & P125FAK PROTEIN were indexed under PROTEIN-TYROSINE KINASE 2001-2005, & under CELL ADHESION MOLECULES 1990-2000, & MEMBRANE GLYCOPROTEINS 1987-1992, MEMBRANE PROTEINS 1986-1987 |
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| History Note: | 2006(1986) |
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| DeCS ID: | 50729 | ||||||
| Unique ID: | D051417 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2006/01/01 | ||||||
| Date of Entry: | 2005/06/30 | ||||||
| Revision Date: | 2015/11/23 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Focal Adhesion Kinase 1
- Preferred
| Concept UI |
M0142569 |
| Scope note | A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION. |
| Preferred term | Focal Adhesion Kinase 1 |
| Entry term(s) |
Endogenous Substrate pp120 Focal Adhesion Associated Protein Tyrosine Kinase pp125FAK Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK Protein Tyrosine Kinase 2 p125FAK Protein |
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