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Descriptor English: Integrin-Binding Sialoprotein
Descriptor Spanish: Sialoproteína de Unión a Integrina
Descriptor sialoproteína de unión a integrinas
Scope note: Fosfoproteína muy glicosilada y sulfatada que se encuentra casi exclusivamente en los tejidos conjuntivos mineralizados. Es una proteína de la matriz extracelulalr que se une a la hidroxiapatita por una secuencia de ácido poliglutámico y media en la unión celular a través de una secuencia RGD.
Descriptor Portuguese: Sialoproteína de Ligação à Integrina
Descriptor French: Sialoprotéine liant les intégrines
Entry term(s): Bone Sialoprotein
Bone Sialoprotein 2
Bone Sialoprotein II
Integrin Binding Sialoprotein
Sialoprotein 2, Bone
Sialoprotein, Bone
Sialoprotein, Integrin-Binding
Tree number(s): D09.400.430.950.675
D12.776.395.700.675
D12.776.744.527
D12.776.860.300.562
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D058574
Scope note: A highly glycosylated and sulfated phosphoprotein that is found almost exclusively in mineralized connective tissues. It is an extracellular matrix protein that binds to hydroxyapatite through polyglutamic acid sequences and mediates cell attachment through an RGD sequence.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2011; INTEGRIN-BINDING SIALOPROTEIN was indexed under SIALOGLYCOPROTEINS 2005-2010, and under GLYCOPROTEINS 1989-2004
History Note: 2011
DeCS ID: 54093
Unique ID: D058574
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2011/01/01
Date of Entry: 2010/06/25
Integrin-Binding Sialoprotein - Preferred
Concept UI M0543316
Scope note A highly glycosylated and sulfated phosphoprotein that is found almost exclusively in mineralized connective tissues. It is an extracellular matrix protein that binds to hydroxyapatite through polyglutamic acid sequences and mediates cell attachment through an RGD sequence.
Preferred term Integrin-Binding Sialoprotein
Entry term(s) Bone Sialoprotein
Bone Sialoprotein 2
Bone Sialoprotein II
Integrin Binding Sialoprotein
Sialoprotein 2, Bone
Sialoprotein, Bone
Sialoprotein, Integrin-Binding



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