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Descriptor English: Fanconi Anemia Complementation Group D2 Protein
Descriptor Spanish: Proteína del Grupo de Complementación D2 de la Anemia de Fanconi
Descriptor proteína del grupo de complementación D2 de la anemia de Fanconi
Scope note: Proteína del grupo de complementación de la anemia de Fanconi, monoubicuitinizada por la PROTEÍNA FANCL como respuesta a DAÑOS DEL ADN. En respuesta a las RADIACIONES IONIZANTES puede sufrir FOSFORILACIÓN por la acción de la PROTEÍNA MUTADA DE LA ATAXIA TELEANGIECTASIA. La proteína FANCD2 modificada interacciona con la PROTEÍNA BRCA2 en un complejo estable con CROMATINA, y está implicada en la REPARACIÓN DEL ADN mediante RECOMBINACIÓN homóloga.
Descriptor Portuguese: Proteína do Grupo de Complementação D2 da Anemia de Fanconi
Descriptor French: Protéine du groupe de complémentation D2 de l'anémie de Fanconi
Entry term(s): FANCD2 Protein
Fanconi Anemia Group D2 Complementing Protein
Fanconi Anemia Group D2 Protein
Tree number(s): D12.776.313.812
D12.776.660.285
D12.776.744.484
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D052236
Scope note: A Fanconi anemia complementation group protein that undergoes mono-ubiquitination by FANCL PROTEIN in response to DNA DAMAGE. Also, in response to IONIZING RADIATION it can undergo PHOSPHORYLATION by ataxia telangiectasia mutated protein. Modified FANCD2 interacts with BRCA2 PROTEIN in a stable complex with CHROMATIN, and it is involved in DNA REPAIR by homologous RECOMBINATION.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2006; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN was indexed under NUCLEAR PROTEINS 2001-2005
History Note: 2006(2001)
DeCS ID: 51070
Unique ID: D052236
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2009/07/20
Fanconi Anemia Complementation Group D2 Protein - Preferred
Concept UI M0383516
Scope note A Fanconi anemia complementation group protein that undergoes mono-ubiquitination by FANCL PROTEIN in response to DNA DAMAGE. Also, in response to IONIZING RADIATION it can undergo PHOSPHORYLATION by ataxia telangiectasia mutated protein. Modified FANCD2 interacts with BRCA2 PROTEIN in a stable complex with CHROMATIN, and it is involved in DNA REPAIR by homologous RECOMBINATION.
Preferred term Fanconi Anemia Complementation Group D2 Protein
Entry term(s) FANCD2 Protein
Fanconi Anemia Group D2 Complementing Protein
Fanconi Anemia Group D2 Protein



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