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Descriptor English: mTOR Associated Protein, LST8 Homolog
Descriptor Spanish: Homóloga LST8 de la Proteína Asociada al mTOR
Descriptor Portuguese: Homólogo LST8 da Proteína Associada a mTOR
Descriptor French: Protéine homologue de LST8 associée à mTOR
Entry term(s): G protein beta Subunit like Polypeptide
G protein beta Subunit-like Polypeptide
GBetaL Protein
mLST8 Protein
Tree number(s): D05.500.337.250
D08.811.913.696.620.682.700.931.500.250
D12.644.360.024.310
D12.776.157.057.073
D12.776.476.024.389
D12.776.476.925.500.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000076242
Scope note: An adaptor protein, consisting of seven WD REPEATS along its length, that functions as a component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 and MTORC2 COMPLEX. It interacts directly with MTOR to enhance its kinase activity and stabilizes the MTOR-RPTOR PROTEIN interaction in nutrient-poor conditions, favoring RPTOR inhibition of MTOR activity.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Adaptor Proteins, Signal Transducing (2013-2017)
Proteins (2011-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 56983
Unique ID: D000076242
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
mTOR Associated Protein, LST8 Homolog - Preferred
Concept UI M000632423
Scope note An adaptor protein, consisting of seven WD REPEATS along its length, that functions as a component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 and MTORC2 COMPLEX. It interacts directly with MTOR to enhance its kinase activity and stabilizes the MTOR-RPTOR PROTEIN interaction in nutrient-poor conditions, favoring RPTOR inhibition of MTOR activity.
Preferred term mTOR Associated Protein, LST8 Homolog
Entry term(s) G protein beta Subunit like Polypeptide
G protein beta Subunit-like Polypeptide
GBetaL Protein
mLST8 Protein



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