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Descriptor English: Mechanistic Target of Rapamycin Complex 1
Descriptor Spanish: Diana Mecanicista del Complejo 1 de la Rapamicina
Descriptor diana mecanicista del complejo 1 de la rapamicina
Entry term(s) TORC1
complejo TOR 1
complejo mTORC1
diana del complejo 1 de la rapamicina
mTORC1
Scope note: Complejo multiproteico evolutivamente conservado que funciona como sensor de la energía celular y regulador de la síntesis de proteínas para el crecimiento y la proliferación celular. Está formado por SERINA-TREONINA QUINASAS TOR, la PROTEÍNA REGULADORA ASOCIADA A MTOR (RAPTOR), la PROTEÍNA MLST8 y la proteína sustrato 1 de AKT1. La actividad del complejo está regulada por SIROLIMUS, INSULINA, FACTORES DE CRECIMIENTO, ÁCIDOS FOSFATÍDICOS, algunos aminoácidos o derivados de aminoácidos y el ESTRÉS OXIDATIVO.
Descriptor Portuguese: Alvo Mecanístico do Complexo 1 de Rapamicina
Descriptor French: Complexe-1 cible mécanistique de la rapamycine
Entry term(s): Complexe TOR-1
Complexe mTORC1
Complexe-1 cible de la rapamycine
Complexe-1 cible de la rapamycine chez les mammifères
TORC1
mTORC1
Tree number(s): D05.500.337
D08.811.913.696.620.682.700.931.500
D12.776.476.563.931.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000076222
Scope note: An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Registry Number: EC 2.7.11.1
DeCS ID: 56982
Unique ID: D000076222
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
Complexe-1 cible mécanistique de la rapamycine - Preferred
Concept UI M0579317
Preferred term Complexe-1 cible mécanistique de la rapamycine
Entry term(s) Complexe TOR-1
Complexe mTORC1
Complexe-1 cible de la rapamycine
Complexe-1 cible de la rapamycine chez les mammifères
TORC1
mTORC1



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