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Descriptor English: Factor XIIa
Descriptor Spanish: Factor XIIa
Descriptor Portuguese: Fator XIIa
Descriptor French: Facteur XIIa
Entry term(s): Activated Factor XII
Activator, Prekallikrein
Blood Coagulation Factor XII, Activated
Coagulation Factor XIIa
Factor 12A
Factor Twelve A
Factor XII, Activated
Factor XIIa, Coagulation
Fragments, Hageman-Factor
Hageman Factor Fragments
Hageman-Factor Fragments
Prekallikrein Activator
Tree number(s): D08.811.277.656.300.760.324
D08.811.277.656.959.350.324
D12.776.124.125.450.324
D23.119.450.324
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015956
Scope note: Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
Annotation: /defic = FACTOR XII DEFICIENCY
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.21.38
Previous Indexing: Factor XII (1966-1989)
Peptide Fragments (1979-1987)
Serine Proteinases (1988-1989)
Public MeSH Note: 90
History Note: 90
Related: Coagulants MeSH
DeCS ID: 24648
Unique ID: D015956
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2017/02/24
Factor XIIa - Preferred
Concept UI M0024400
Scope note Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
Preferred term Factor XIIa
Entry term(s) Activated Factor XII
Activator, Prekallikrein
Blood Coagulation Factor XII, Activated
Coagulation Factor XIIa
Factor 12A
Factor Twelve A
Factor XII, Activated
Factor XIIa, Coagulation
Prekallikrein Activator
Hageman-Factor Fragments - Narrower
Concept UI M0024401
Preferred term Hageman-Factor Fragments
Entry term(s) Fragments, Hageman-Factor
Hageman Factor Fragments



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