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Descriptor in English: Lymphotoxin-alpha
Descriptor in Spanish: Linfotoxina-alfa
Descriptor in Portuguese: Linfotoxina-alfa
Descriptor in French: Lymphotoxine alpha
Entry term(s): Lymphotoxin
Lymphotoxin alpha
Lymphotoxin alpha3
Lymphotoxin-alpha, Soluble
Lymphotoxin-alpha3
Soluble Lymphotoxin alpha
Soluble Lymphotoxin-alpha
TNF Superfamily, Member 1
TNF-beta
Tumor Necrosis Factor Ligand Superfamily Member 1
Tumor Necrosis Factor beta
Tumor Necrosis Factor-beta
alpha Lymphotoxin
alpha-Lymphotoxin
Tree number(s): D12.644.276.374.480.438
D12.644.276.374.750.500
D12.776.467.374.480.438
D12.776.467.374.750.500
D23.529.374.480.438
D23.529.374.750.500
Scope note: A tumor necrosis factor family member that is released by activated LYMPHOCYTES. Soluble lymphotoxin is specific for TUMOR NECROSIS FACTOR RECEPTOR TYPE I; TUMOR NECROSIS FACTOR RECEPTOR TYPE II; and TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 14. Lymphotoxin-alpha can form a membrane-bound heterodimer with LYMPHOTOXIN-BETA that has specificity for the LYMPHOTOXIN BETA RECEPTOR.
Annotation: for "lymphocytotoxin" use CYTOTOXINS and LYMPHOCYTES
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
History Note: 2007 (1974-1977); for TUMOR NECROSIS FACTOR-BETA & TNF-BETA use TUMOR NECROSIS FACTOR 1988-1989
DeCS UI: 29490
Descriptor UI: D008233
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2015/06/23
Lymphotoxin-alpha - Preferred
Concept UI M0012828
Scope note A tumor necrosis factor family member that is released by activated LYMPHOCYTES. Soluble lymphotoxin is specific for TUMOR NECROSIS FACTOR RECEPTOR TYPE I; TUMOR NECROSIS FACTOR RECEPTOR TYPE II; and TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 14. Lymphotoxin-alpha can form a membrane-bound heterodimer with LYMPHOTOXIN-BETA that has specificity for the LYMPHOTOXIN BETA RECEPTOR.
Preferred term Lymphotoxin-alpha
Entry term(s) Lymphotoxin
Lymphotoxin alpha
TNF Superfamily, Member 1
TNF-beta
Tumor Necrosis Factor Ligand Superfamily Member 1
Tumor Necrosis Factor beta
Tumor Necrosis Factor-beta
alpha Lymphotoxin
alpha-Lymphotoxin
Lymphotoxin-alpha3 - Narrower
Concept UI M0276797
Preferred term Lymphotoxin-alpha3
Entry term(s) Lymphotoxin alpha3
Lymphotoxin-alpha, Soluble
Soluble Lymphotoxin alpha
Soluble Lymphotoxin-alpha



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