| Descriptor English: | Valosin Containing Protein | ||||||
| Descriptor Spanish: |
Proteína que Contiene Valosina
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| Descriptor Portuguese: | Proteína com Valosina | ||||||
| Descriptor French: | Protéine contenant la valosine | ||||||
| Entry term(s): |
CDC48 Protein Cell Cycle Protein CDC48 Cell Cycle Protein CDC48p Valosin-Containing Protein Valosin-Containing Protein, p97 Valosine Containing Protein Valosine-Containing Protein p97 Valosin Containing Protein p97 Valosin-Containing Protein |
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| Tree number(s): |
D08.811.277.040.013.500.750 D08.811.277.040.025.024.750 D12.776.157.025.750.750 D12.776.167.800 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000074405 | ||||||
| Scope note: | A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 3.6.4.6 | ||||||
| Public MeSH Note: | 2018; VALOSIN CONTAINING PROTEIN was indexed under ADENOSINE TRIPHOSPHATASES and CELL CYCLE PROTEINS 1991-2017 |
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| History Note: | 2018 (1991) |
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| DeCS ID: | 56996 | ||||||
| Unique ID: | D000074405 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/06/02 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Valosin Containing Protein
- Preferred
| Concept UI |
M000626473 |
| Scope note | A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients. |
| Preferred term | Valosin Containing Protein |
| Entry term(s) |
CDC48 Protein Cell Cycle Protein CDC48 Cell Cycle Protein CDC48p Valosin-Containing Protein Valosin-Containing Protein, p97 Valosine Containing Protein Valosine-Containing Protein p97 Valosin Containing Protein p97 Valosin-Containing Protein |
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