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Descriptor English: F-Box-WD Repeat-Containing Protein 7
Descriptor Spanish: Proteína 7 que Contiene Repeticiones F-Box-WD
Descriptor proteína 7 que contiene repeticiones F-Box-WD
Entry term(s) proteína 7 que contiene dominios F-Box y WD-40
proteína FBXW7
Scope note: Componente de SCF (FBW7) UBIQUITINA LIGASA que contiene un motivo F-box y múltiples REPETICIONES WD. Reconoce y une señales fosforiladas en diversas proteínas implicadas en la PROLIFERACIÓN CELULAR y las dirige al complejo SCF para la UBIQUITINACIÓN. Sus dianas son la CICLINA E, las PROTEÍNAS PROTO-ONCOGÉNICAS C-JUN, las PROTEÍNAS PROTO-ONCOGÉNICAS C-MYC y las PROTEÍNAS QUINASAS JNK ACTIVADAS POR MITÓGENOS.
Descriptor Portuguese: Proteína 7 com Repetições F-Box-WD
Descriptor French: Protéine-7 contenant une boite F et des répétitions WD
Entry term(s): F Box WD Repeat Containing Protein 7
F Box and WD 40 Domain Containing Protein 7
F-Box and WD-40 Domain-Containing Protein 7
FBXW7 Protein
Tree number(s): D08.811.464.938.750.750.750
D12.776.157.169.750
D12.776.167.242
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000073979
Scope note: A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Cell Cycle Proteins (2006-2017)
F-Box Proteins (2006-2017)
Ubiquitin-Protein Ligases (2006-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57012
Unique ID: D000073979
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/02/27
F-Box-WD Repeat-Containing Protein 7 - Preferred
Concept UI M000625118
Scope note A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES.
Preferred term F-Box-WD Repeat-Containing Protein 7
Entry term(s) F Box WD Repeat Containing Protein 7
F Box and WD 40 Domain Containing Protein 7
F-Box and WD-40 Domain-Containing Protein 7
FBXW7 Protein



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