Search
Descriptor English: Mad2 Proteins
Descriptor Spanish: Proteínas Mad2
Descriptor proteínas Mad2
Scope note: Mad2 es un componente del punto de control del ensamblaje del huso acromático. Se une e inhibe a la subunidad activadora del complejo promotor de la anafase, Cdc20, impidiendo el comienzo de la anafase hasta que todos los cromosomas están adecuadamente alineados en la placa ecuatorial. La Mad2 es necesaria para la captura apropiada de los microtúbulos en CINETOCOROS.
Descriptor Portuguese: Proteínas Mad2
Descriptor French: Protéines Mad2
Entry term(s): Mad2 Mitotic Arrest Deficient-like 1 Proteins
Tree number(s): D12.776.167.313
D12.776.660.526
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D064246
Scope note: Mad2 is a component of the spindle-assembly checkpoint apparatus. It binds to and inhibits the Cdc20 activator subunit of the anaphase-promoting complex, preventing the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Mad2 is required for proper microtubule capture at KINETOCHORES.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2014; was indexed under CELL CYCLE PROTEINS 2000-2013 and NUCLEAR PROTEINS 2005-2013
History Note: 2014
DeCS ID: 55327
Unique ID: D064246
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Mad2 Proteins - Preferred
Concept UI M0580530
Scope note Mad2 is a component of the spindle-assembly checkpoint apparatus. It binds to and inhibits the Cdc20 activator subunit of the anaphase-promoting complex, preventing the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Mad2 is required for proper microtubule capture at KINETOCHORES.
Preferred term Mad2 Proteins
Entry term(s) Mad2 Mitotic Arrest Deficient-like 1 Proteins



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.

Go to survey