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Descriptor in English: Separase
Descriptor in Spanish: Separasa
Descriptor in Portuguese: Separase
Descriptor in French: Separase
Tree number(s): D08.811.277.656.262.500.792
D08.811.277.656.300.200.792
D12.776.167.552
Scope note: Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
History Note: 2014
DeCS UI: 55268
Descriptor UI: D064247
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Separase - Preferred
Concept UI M0580540
Scope note Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation.
Preferred term Separase



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