| Descriptor English: | Botulinum Toxins | ||||||
| Descriptor Spanish: |
Toxinas Botulínicas
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| Descriptor Portuguese: | Toxinas Botulínicas | ||||||
| Descriptor French: | Toxines botuliniques | ||||||
| Entry term(s): |
Botulin Botulinum Neurotoxin Botulinum Neurotoxins Botulinum Toxin Clostridium botulinum Toxins Neurotoxin, Botulinum Neurotoxins, Botulinum Toxin, Botulinum Toxins, Botulinum Toxins, Clostridium botulinum |
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| Tree number(s): |
D08.811.277.656.300.480.153 D08.811.277.656.675.374.153 D12.776.097.156 D23.946.123.179 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D001905 | ||||||
| Scope note: | Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS. |
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| Annotation: | /antag permitted but consider also BOTULINUM ANTITOXIN |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Pharm Action: |
Neurotoxins Acetylcholine Release Inhibitors |
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| Registry Number: | EC 3.4.24.69 | ||||||
| Previous Indexing: |
Clostridium Botulinum (1966-1968) Toxins (1966-1968) |
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| Public MeSH Note: | 78; was BOTULINUM TOXIN 1972-77 |
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| Online Note: | use BOTULINUM TOXINS to search BOTULINUM TOXIN 1969-77 (as Prov 1969-71) |
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| History Note: | 78; was BOTULINUM TOXIN 1969-77 (Prov 1969-71) |
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| Related: |
Botulism
MeSH | ||||||
| DeCS ID: | 1930 | ||||||
| Unique ID: | D001905 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1972/01/01 | ||||||
| Date of Entry: | 1999/01/01 | ||||||
| Revision Date: | 2020/05/27 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors
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Botulinum Toxins
- Preferred
| Concept UI |
M0002844 |
| Scope note | Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS. |
| Preferred term | Botulinum Toxins |
| Entry term(s) |
Botulin Botulinum Neurotoxin Botulinum Neurotoxins Botulinum Toxin Clostridium botulinum Toxins Neurotoxin, Botulinum Neurotoxins, Botulinum Toxin, Botulinum Toxins, Botulinum Toxins, Clostridium botulinum |
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