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Descriptor English: Mucin-4
Descriptor Spanish: Mucina 4
Descriptor mucina 4
Scope note: Mucina transmembranaria que se encuentra en distintos tejidos epiteliales. Puede desempeñar un papel en la regulación de la adhesión celular y en la señalización de la superficie celular mediante el RECEPTOR ERBB-2. La mucina 4 es un heterodímero de cadenas alfa y beta que proceden de la proteólisis de una proteína precursora. 
Descriptor Portuguese: Mucina-4
Descriptor French: Mucine-4
Entry term(s): ASGP-1
ASGP-2
Ascites Sialoglycoprotein 1
Ascites Sialoglycoprotein 2
Mucin 4
Mucin 4 alpha chain
Mucin 4 beta Chain
Mucin-4 alpha chain
Mucin-4 beta Chain
Sialoglycoprotein 1, Ascites
Tree number(s): D09.400.430.900.631.195
D12.644.360.534
D12.776.395.560.631.195
D12.776.476.534
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D055264
Scope note: A transmembrane mucin that is found in a broad variety of epithelial tissue. Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. Mucin-4 is a heterodimer of alpha and beta chains. The alpha and beta chains result from the proteolytic cleavage of a precursor protein.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2009; MUCIN-4 was indexed under MUCINS 1997-2008; ASCITES SIALOGLYCOPROTEIN 1 was indexed under SIALOGLYCOPROTEINS 1986-2008; SIALOGLYCOPROTEIN 2 was indexed under SIALOGLYCOPROTEINS 1988-2008
History Note: 2009(1986)
DeCS ID: 53150
Unique ID: D055264
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2009/01/01
Date of Entry: 2008/07/08
Revision Date: 2015/11/24
Mucin-4 - Preferred
Concept UI M0280004
Scope note A transmembrane mucin that is found in a broad variety of epithelial tissue. Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. Mucin-4 is a heterodimer of alpha and beta chains. The alpha and beta chains result from the proteolytic cleavage of a precursor protein.
Preferred term Mucin-4
Entry term(s) Mucin 4
Mucin-4 beta Chain - Narrower
Concept UI M0160424
Preferred term Mucin-4 beta Chain
Entry term(s) ASGP-2
Ascites Sialoglycoprotein 2
Mucin 4 beta Chain
Mucin-4 alpha chain - Narrower
Concept UI M0516135
Preferred term Mucin-4 alpha chain
Entry term(s) ASGP-1
Ascites Sialoglycoprotein 1
Mucin 4 alpha chain
Sialoglycoprotein 1, Ascites



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