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Descriptor English: Activating Transcription Factor 6
Descriptor Spanish: Factor de Transcripción Activador 6
Descriptor factor de transcripción activador 6
Scope note: Uno de los FACTORES DE TRANSCRIPCIÓN DE CREMALLERA DE LEUCINAS DE NATURALEZA BÁSICA que se sintetiza en el RETÍCULO ENDOPLÁSMICO como proteína de unión a la membrana. En respuesta al estrés del retículo endoplásmico se transloca al APARATO DE GOLGI. Es activado por PROTEASAS y a continuación se traslada al NÚCLEO CELULAR para regular la TRANSCRIPCIÓN GENÉTICA de GENES implicados en la respuesta de las proteínas no plegadas.
Descriptor Portuguese: Fator 6 Ativador da Transcrição
Descriptor French: Facteur de transcription ATF-6
Entry term(s): ATF6 Transcription Factor
Transcription Factor, ATF6
Tree number(s): D12.644.360.011
D12.776.260.108.061.968
D12.776.476.011
D12.776.930.127.061.968
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D051702
Scope note: One of the BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS that is synthesized as a membrane-bound protein in the ENDOPLASMIC RETICULUM. In response to endoplasmic reticulum stress it translocates to the GOLGI APPARATUS. It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2006; ACTIVATING TRANSCRIPTION FACTOR 6 was indexed under DNA-BINDING PROTEINS & TRANSCRIPTION FACTORS 1997-2005
History Note: 2006(1997)
DeCS ID: 50762
Unique ID: D051702
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2015/11/23
Activating Transcription Factor 6 - Preferred
Concept UI M0280604
Scope note One of the BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS that is synthesized as a membrane-bound protein in the ENDOPLASMIC RETICULUM. In response to endoplasmic reticulum stress it translocates to the GOLGI APPARATUS. It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response.
Preferred term Activating Transcription Factor 6
Entry term(s) ATF6 Transcription Factor
Transcription Factor, ATF6



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