| Descriptor English: | RNA-Binding Protein EWS | ||||||
| Descriptor Spanish: |
Proteína EWS de Unión a ARN
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| Descriptor Portuguese: | Proteína EWS de Ligação a RNA | ||||||
| Descriptor French: | Protéine EWS de liaison à l'ARN | ||||||
| Entry term(s): |
EWS Protein EWS Proto Oncogene Protein EWS Proto-Oncogene Protein EWS RNA Binding Protein 1 EWS, RNA-Binding Protein EWSR1 Protein Ewing Sarcoma Breakpoint Region 1 Protein Ewing Sarcoma Breakpointregion 1 Protein Protein, EWSR1 Proto-Oncogene Protein, EWS RNA Binding Protein EWS |
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| Tree number(s): |
D12.644.360.650 D12.776.157.142.750 D12.776.157.725.500.313.900 D12.776.157.725.813.750.900 D12.776.476.650 D12.776.624.664.700.913 D12.776.664.962.500.313.900 D12.776.664.962.813.750.900 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D034802 | ||||||
| Scope note: | A ubiquitous hnRNP protein that contains an RNA RECOGNITION MOTIF and C-terminal ranBP2-type zinc finger. It localizes to the CELL NUCLEUS and CYTOPLASM and is expressed as different isoforms in various tissues, interacting with CALMODULIN and TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. Translocations that result in the formation of fusion proteins containing parts of RNA-binding protein EWS are associated with EWING SARCOMA. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Ribonucleoproteins (1995-2002) |
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| Public MeSH Note: | 2003; EWS PROTEIN was indexed under RIBONUCLEOPROTEINS 1995-2002 |
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| History Note: | 2003; for EWS PROTEIN use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS 1995-2002 |
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| Related: |
Zinc Fingers
MeSH | ||||||
| DeCS ID: | 37419 | ||||||
| Unique ID: | D034802 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2003/01/01 | ||||||
| Date of Entry: | 2002/07/03 | ||||||
| Revision Date: | 2017/06/29 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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RNA-Binding Protein EWS
- Preferred
| Concept UI |
M0087091 |
| Scope note | A ubiquitous hnRNP protein that contains an RNA RECOGNITION MOTIF and C-terminal ranBP2-type zinc finger. It localizes to the CELL NUCLEUS and CYTOPLASM and is expressed as different isoforms in various tissues, interacting with CALMODULIN and TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. Translocations that result in the formation of fusion proteins containing parts of RNA-binding protein EWS are associated with EWING SARCOMA. |
| Preferred term | RNA-Binding Protein EWS |
| Entry term(s) |
EWS Protein EWS Proto Oncogene Protein EWS Proto-Oncogene Protein EWS RNA Binding Protein 1 EWS, RNA-Binding Protein EWSR1 Protein Ewing Sarcoma Breakpoint Region 1 Protein Ewing Sarcoma Breakpointregion 1 Protein Protein, EWSR1 Proto-Oncogene Protein, EWS RNA Binding Protein EWS |
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