| Descriptor English: | Tuberous Sclerosis Complex 1 Protein | ||||||
| Descriptor Spanish: |
Proteína 1 del Complejo de la Esclerosis Tuberosa
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| Descriptor Portuguese: | Proteína 1 do Complexo Esclerose Tuberosa | ||||||
| Descriptor French: | Protéine-1 du complexe de la sclérose tubéreuse | ||||||
| Entry term(s): |
Hamartin |
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| Tree number(s): |
D12.644.360.925 D12.776.476.932 D12.776.624.776.766 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000077004 | ||||||
| Scope note: | An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN (TSC2) and other signaling factors to negatively regulate MTORC1 signaling and affect cell growth and proliferation. Structurally, it interacts with TSC2 through its N-terminal, which also contains GSK-3BETA phosphorylation sites and a RHO-KINASE activation domain. It also contains a C-terminal coiled-coil domain and ezrin-radixin-moesin (ERM) domain. Mutations in the TSC1 gene are associated with TUBEROUS SCLEROSIS. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Public MeSH Note: | 2019; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN was indexed under TUMOR SUPPRESSOR PROTEINS 2006-2018 and under PROTEINS 1997-2005 |
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| History Note: | 2019 (1997) |
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| DeCS ID: | 57502 | ||||||
| Unique ID: | D000077004 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2019/01/01 | ||||||
| Date of Entry: | 2018/07/09 | ||||||
| Revision Date: | 2019/04/29 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Tuberous Sclerosis Complex 1 Protein
- Preferred
| Concept UI |
M0279212 |
| Scope note | An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN (TSC2) and other signaling factors to negatively regulate MTORC1 signaling and affect cell growth and proliferation. Structurally, it interacts with TSC2 through its N-terminal, which also contains GSK-3BETA phosphorylation sites and a RHO-KINASE activation domain. It also contains a C-terminal coiled-coil domain and ezrin-radixin-moesin (ERM) domain. Mutations in the TSC1 gene are associated with TUBEROUS SCLEROSIS. |
| Preferred term | Tuberous Sclerosis Complex 1 Protein |
| Entry term(s) |
Hamartin |
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