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Descriptor English: Asialoglycoproteins
Descriptor Spanish: Asialoglicoproteínas
Descriptor asialoglicoproteínas
Entry term(s) asialoglicoproteína
glicoproteínas desializadas
Scope note: Glicoproteínas endógenas de las que se ha eliminado el ÁCIDO SIÁLICO por acción de las sialidasas. Las asialoglicoproteínas se unen fuertemente al RECEPTOR DE ASIALOGLICOPROTEÍNAS localizado en las membranas plasmáticas de los hepatocitos. Tras la internalización mediante ENDOCITOSIS adsortiva, llegan hasta los LISOSOMAS para su degradación. Por tanto, la desaparición mediada por el receptor de las asialoglicoproteínas constituye un aspecto importante en el recambio de las glicoproteínas plasmáticas. Están elevadas en el plasma de pacientes con CIRROSIS HEPÁTICA o HEPATÍTIS.
Descriptor Portuguese: Assialoglicoproteínas
Descriptor French: Asialoglycoprotéines
Entry term(s): Asialoglycoprotein
Desialylated Glycoproteins
Glycoproteins, Desialylated
Tree number(s): D09.400.430.657
D12.776.395.140
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D001212
Scope note: Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Glycoproteins (1966-1984)
Public MeSH Note: 85
History Note: 85
Related: Asialoglycoprotein Receptor MeSH
DeCS ID: 1219
Unique ID: D001212
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1985/01/01
Date of Entry: 1984/05/30
Revision Date: 2005/07/13
Asialoglycoproteins - Preferred
Concept UI M0001810
Scope note Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.
Preferred term Asialoglycoproteins
Entry term(s) Asialoglycoprotein
Desialylated Glycoproteins
Glycoproteins, Desialylated



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