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Descriptor English: Lactoferrin
Descriptor Spanish: Lactoferrina
Descriptor lactoferrina
Scope note: Proteína que se une al hierro caracterizada inicialmente como una proteína de la leche. Se halla ampliamente distribuida en las secreciones y se encuentra en los gránulos neutrofílicos de los LEUCOCITOS. El extremo N de la lactoferrina posee una serina proteasa que inactiva el SISTEMA DE SECRECIÓN TIPO III utilizado por las bacterias con el fin de exportar las proteínas de virulencia para la invasión de la célula huésped.
Descriptor Portuguese: Lactoferrina
Descriptor French: Lactoferrine
Entry term(s): Lactotransferrin
Tree number(s): D08.811.277.656.300.760.471
D08.811.277.656.959.350.471
D09.400.430.887
D12.776.157.427.750.249
D12.776.256.159.750.816.500.507
D12.776.377.457.507
D12.776.395.507
D12.776.556.579.750.249
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007781
Scope note: An iron-binding protein that was originally characterized as a milk protein. It is widely distributed in secretory fluids and is found in the neutrophilic granules of LEUKOCYTES. The N-terminal part of lactoferrin possesses a serine protease which functions to inactivate the TYPE III SECRETION SYSTEM used by bacteria to export virulence proteins for host cell invasion.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Anti-Infective Agents
Registry Number: EC 3.4.21.-
Public MeSH Note: 91; was see under LACTOGLOBULINS 1973-90
History Note: 91(73); was see under LACTOGLOBULINS 1973-90
DeCS ID: 7958
Unique ID: D007781
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1999/01/01
Revision Date: 2015/06/26
Lactoferrin - Preferred
Concept UI M0012165
Scope note An iron-binding protein that was originally characterized as a milk protein. It is widely distributed in secretory fluids and is found in the neutrophilic granules of LEUKOCYTES. The N-terminal part of lactoferrin possesses a serine protease which functions to inactivate the TYPE III SECRETION SYSTEM used by bacteria to export virulence proteins for host cell invasion.
Preferred term Lactoferrin
Entry term(s) Lactotransferrin



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