| Descriptor English: | Complement C1 Inhibitor Protein | ||||||
| Descriptor Spanish: |
Proteína Inhibidora del Complemento C1
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| Descriptor Portuguese: | Proteína Inibidora do Complemento C1 | ||||||
| Descriptor French: | C1 Inhibiteur | ||||||
| Entry term(s): |
C1 Esterase Inhibitor C1 INH Protein C1 Inhibitor Protein C1-INH Protein C1-Inhibitor Protein Complement C1-Inhibitor Protein Esterase Inhibitor, C1 G1, Serpin Plasma Protease C1 Inhibitor SERPING1 Serpin Family G Member 1 Serpin G1 |
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| Tree number(s): |
D09.400.430.780 D12.644.861.140.500 D12.776.124.486.274.920.250.500 D12.776.395.320 D12.776.872.140.500 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D050718 | ||||||
| Scope note: | An endogenous 105-kDa plasma glycoprotein produced primarily by the LIVER and MONOCYTES. It inhibits a broad spectrum of proteases, including the COMPLEMENT C1R and the COMPLEMENT C1S proteases of the CLASSICAL COMPLEMENT PATHWAY, and the MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. C1-INH-deficient individuals suffer from HEREDITARY ANGIOEDEMA TYPES I AND II. |
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| Annotation: | do not confuse with COMPLEMENT C1 INACTIVATOR PROTEINS |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AN analysis BI biosynthesis CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Entry Combination: |
deficiency:Hereditary Angioedema Types I and II
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| Pharm Action: |
Complement Inactivating Agents |
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| Previous Indexing: |
Complement C1 Inactivator Proteins (1970-2005) |
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| Public MeSH Note: | 2006; for C1 ESTERASE INHIBITOR see COMPLEMENT C1 INACTIVATOR PROTEINS |
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| History Note: | 2006; for C1 ESTERASE INHIBITOR use COMPLEMENT C1 INACTIVATOR PROTEINS |
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| Entry Version: | C 1 INH |
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| DeCS ID: | 50836 | ||||||
| Unique ID: | D050718 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2006/01/01 | ||||||
| Date of Entry: | 2005/06/30 | ||||||
| Revision Date: | 2017/02/27 |
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CHEMICALS AND DRUGS
Carbohydrates [D09]Carbohydrates -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Complement C1 Inhibitor Protein
- Preferred
| Concept UI |
M0476632 |
| Scope note | An endogenous 105-kDa plasma glycoprotein produced primarily by the LIVER and MONOCYTES. It inhibits a broad spectrum of proteases, including the COMPLEMENT C1R and the COMPLEMENT C1S proteases of the CLASSICAL COMPLEMENT PATHWAY, and the MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. C1-INH-deficient individuals suffer from HEREDITARY ANGIOEDEMA TYPES I AND II. |
| Preferred term | Complement C1 Inhibitor Protein |
| Entry term(s) |
C1 Esterase Inhibitor C1 INH Protein C1 Inhibitor Protein C1-INH Protein C1-Inhibitor Protein Complement C1-Inhibitor Protein Esterase Inhibitor, C1 G1, Serpin Plasma Protease C1 Inhibitor SERPING1 Serpin Family G Member 1 Serpin G1 |
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