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Descriptor English: Histones
Descriptor Spanish: Histonas
Descriptor histonas
Scope note: Proteínas cromosómicas pequeñas (aproximadamente 12-20 kD) que poseen una estructura abierta, no plegada y unidas al ADN en los núcleos celulares por enlaces iónicos. La clasificación en diversos tipos (denominadas histona I, histona II, etc) se basa en las cantidades relativas de arginina y de lisina en cada una de ellas.
Descriptor Portuguese: Histonas
Descriptor French: Histone
Entry term(s): Histone
Histone H1
Histone H1(s)
Histone H2a
Histone H2b
Histone H3
Histone H3.3
Histone H4
Histone H5
Histone H7
Tree number(s): D12.776.157.687.485
D12.776.660.720.485
D12.776.664.469
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D006657
Scope note: Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.
Annotation: H1, H2a, H2b, H3, etc. go here
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
DeCS ID: 23282
Unique ID: D006657
NLM Classification: QU 56
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24
Histones - Preferred
Concept UI M0010429
Scope note Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.
Preferred term Histones
Entry term(s) Histone
Histone H1(s) - Narrower
Concept UI M0010423
Preferred term Histone H1(s)
Histone H2a - Narrower
Concept UI M0010424
Preferred term Histone H2a
Histone H3.3 - Narrower
Concept UI M0010431
Preferred term Histone H3.3
Histone H4 - Narrower
Concept UI M0010426
Preferred term Histone H4
Histone H5 - Narrower
Concept UI M0010427
Preferred term Histone H5
Histone H7 - Narrower
Concept UI M0010428
Preferred term Histone H7
Histone H2b - Narrower
Concept UI M0010430
Preferred term Histone H2b
Histone H1 - Narrower
Concept UI M0010422
Preferred term Histone H1
Histone H3 - Narrower
Concept UI M0010425
Preferred term Histone H3



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