| Descriptor English: | Centromere Protein A | ||||||
| Descriptor Spanish: |
Proteína A Centromérica
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| Descriptor Portuguese: | Proteína Centromérica A | ||||||
| Descriptor French: | Protéine A du centromère | ||||||
| Entry term(s): |
Autoantigens 17K, Centromere CENP A Protein CENP-A Protein CENPA Protein Centromere Autoantigens 17K Centromere Protein 17K |
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| Tree number(s): |
D12.776.157.687.173 D12.776.260.123 D12.776.660.235.100 D12.776.660.720.173 D12.776.664.235.100 D23.050.422.031 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000076247 | ||||||
| Scope note: | A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Public MeSH Note: | 2018; CENTROMERE PROTEIN A was indexed under AUTOANTIGENS 1987-2017 and CHROMOSOMAL PROTEINS, NON-HISTONE 1990-2017; and under NUCLEOPROTEINS 1987-1989 |
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| History Note: | 2018 (1987) |
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| DeCS ID: | 57096 | ||||||
| Unique ID: | D000076247 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/06/29 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors
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Centromere Protein A
- Preferred
| Concept UI |
M0147022 |
| Scope note | A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES. |
| Preferred term | Centromere Protein A |
| Entry term(s) |
Autoantigens 17K, Centromere CENP A Protein CENP-A Protein CENPA Protein Centromere Autoantigens 17K Centromere Protein 17K |
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