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Descriptor English: Werner Syndrome Helicase
Descriptor Spanish: Helicasa del Síndrome de Werner
Descriptor helicasa del síndrome de Werner
Entry term(s) helicasa dependiente de ATP del síndrome de Werner
helicasa tipo RecQ del síndrome de Werner
proteína RECQ3
proteína RECQL2
Scope note: Helicasa y exonucleasa 3'-5' dependiente de ADN. Tiene actividad exonucleasa 3'->5' hacia el ADN bicatenario con un 5'-que sobresale y se une preferentemente a sustratos de ADN que contienen estructuras secundarias alternativas, tales como empalmes de replicación y uniones holliday (vea ADN CRUCIFORME). Mutaciones en el gen WRN están asociadas con el SÍNDROME DE WERNER.
Descriptor Portuguese: Helicase da Síndrome de Werner
Descriptor French: Werner syndrome helicase
Entry term(s): Helicase, Werner Syndrome
RECQ3 Protein
RECQL2 Protein
Werner Syndrome ATP Dependent Helicase
Werner Syndrome ATP-Dependent Helicase
Werner Syndrome RecQ Like Helicase
Werner Syndrome RecQ-Like Helicase
Tree number(s): D08.811.277.040.025.159.249.500
D08.811.277.352.335.375.875
D08.811.277.352.365.290.500
D08.811.399.340.249.500
D12.776.157.687.750
D12.776.660.720.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071657
Scope note: A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.6.4.12
Previous Indexing: Exodeoxyribonucleases (1996-2016)
RecQ Helicases (2006-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56469
Unique ID: D000071657
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2017/05/24
Werner Syndrome Helicase - Preferred
Concept UI M000615275
Scope note A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.
Preferred term Werner Syndrome Helicase
Entry term(s) Helicase, Werner Syndrome
RECQ3 Protein
RECQL2 Protein
Werner Syndrome ATP Dependent Helicase
Werner Syndrome ATP-Dependent Helicase
Werner Syndrome RecQ Like Helicase
Werner Syndrome RecQ-Like Helicase



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