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Descriptor English: DNA (Cytosine-5-)-Methyltransferase 1
Descriptor Spanish: ADN (Citosina-5-)-Metiltransferasa 1
Descriptor Portuguese: DNA (Citosina-5-)-Metiltransferase 1
Descriptor French: DNA (Cytosine-5-)-methyltransferase 1
Entry term(s): DNMT1 Enzyme
Enzyme, DNMT1
Tree number(s): D08.811.913.555.500.350.100.500.500
D12.776.157.687.313
D12.776.660.720.313
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000076123
Scope note: A DNA (cytosine-5-)-methyltransferase that contains a central CxxC type zinc finger motif. It binds poly(ADP)-ribose and its expression is regulated by POLY (ADP-RIBOSE) POLYMERASE-1. DNMT1 methylates CpG residues, with a preference for hemimethylated DNA, and associates with DNA replication sites in S PHASE to maintain the methylation pattern in the newly synthesized strand, which is essential for EPIGENETIC PROCESSES. It also associates with CHROMATIN during G2 PHASE and MITOSIS to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development; mutations in the DNMT1 gene are associated with HEREDITARY SENSORY NEUROPATHY TYPE 1 class E.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.1.1.37
Public MeSH Note: 2018; DNA (CYTOSINE-5-)-METHYLTRASFERASE 1 was indexed under DNA (CYTOSINE-5-)-METHYLTRASFERASES 1999-2017
History Note: 2018 (1999)
Related: Zinc Fingers MeSH
DeCS ID: 57029
Unique ID: D000076123
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
DNA (Cytosine-5-)-Methyltransferase 1 - Preferred
Concept UI M0336557
Scope note A DNA (cytosine-5-)-methyltransferase that contains a central CxxC type zinc finger motif. It binds poly(ADP)-ribose and its expression is regulated by POLY (ADP-RIBOSE) POLYMERASE-1. DNMT1 methylates CpG residues, with a preference for hemimethylated DNA, and associates with DNA replication sites in S PHASE to maintain the methylation pattern in the newly synthesized strand, which is essential for EPIGENETIC PROCESSES. It also associates with CHROMATIN during G2 PHASE and MITOSIS to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development; mutations in the DNMT1 gene are associated with HEREDITARY SENSORY NEUROPATHY TYPE 1 class E.
Preferred term DNA (Cytosine-5-)-Methyltransferase 1
Entry term(s) DNMT1 Enzyme
Enzyme, DNMT1



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