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Descriptor English: X-ray Repair Cross Complementing Protein 1
Descriptor Spanish: Proteína 1 de Reparación por Escisión del Grupo de Complementación Cruzada de las Lesiones por Rayos X
Descriptor Portuguese: Proteína 1 Complementadora Cruzada de Reparo de Raio-X
Descriptor French: Protéine-1 de complémentation croisée de la réparation des lésions induites par les rayons X
Entry term(s): X ray Repair Cross Complementing Protein 1
XRCC1 DNA Repair Protein
XRCC1 Protein
Tree number(s): D12.776.157.687.813
D12.776.260.963
D12.776.660.720.813
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000076105
Scope note: A poly(ADP)-ribose-binding protein that functions in the rejoining of DNA single-strand breaks that arise following treatment with alkylating agents or ionizing radiation. It interacts with DNA LIGASE III and POLY ADP RIBOSE POLYMERASE in BASE EXCISION REPAIR, and may also function in DNA processing and chromosome recombination in GERM CELLS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2018; X-RAY REPAIR CROSS COMPLEMENTING PROTEIN 1 was indexed under DNA-BINDING PROTEINS 1994-2017
History Note: 2018 (1994)
DeCS ID: 57099
Unique ID: D000076105
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
X-ray Repair Cross Complementing Protein 1 - Preferred
Concept UI M0225507
Scope note A poly(ADP)-ribose-binding protein that functions in the rejoining of DNA single-strand breaks that arise following treatment with alkylating agents or ionizing radiation. It interacts with DNA LIGASE III and POLY ADP RIBOSE POLYMERASE in BASE EXCISION REPAIR, and may also function in DNA processing and chromosome recombination in GERM CELLS.
Preferred term X-ray Repair Cross Complementing Protein 1
Entry term(s) X ray Repair Cross Complementing Protein 1
XRCC1 DNA Repair Protein
XRCC1 Protein



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