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Descriptor English: Ataxia Telangiectasia Mutated Proteins
Descriptor Spanish: Proteínas de la Ataxia Telangiectasia Mutada
Descriptor Portuguese: Proteínas Mutadas de Ataxia Telangiectasia
Descriptor French: Protéines mutées dans l'ataxie-télangiectasie
Entry term(s): A T Protein
A-T Protein
AT Mutated Protein
ATM Protein
Mutated Protein, AT
Protein, A-T
Protein, AT Mutated
Tree number(s): D08.811.913.696.620.682.700.097
D12.776.157.687.125
D12.776.660.720.125
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D064007
Scope note: A group of PROTEIN-SERINE-THREONINE KINASES which activate critical signaling cascades in double strand breaks, APOPTOSIS, and GENOTOXIC STRESS such as ionizing ultraviolet A light, thereby acting as a DNA damage sensor. These proteins play a role in a wide range of signaling mechanisms in cell cycle control.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.11.1
Public MeSH Note: 2014; was indexed under PROTEIN KINASES 1983-1992; PROTEIN-SERINE-THREONINE KINASES 1993-2013
History Note: 2014
DeCS ID: 55299
Unique ID: D064007
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 2017/05/24
Ataxia Telangiectasia Mutated Proteins - Preferred
Concept UI M0248389
Scope note A group of PROTEIN-SERINE-THREONINE KINASES which activate critical signaling cascades in double strand breaks, APOPTOSIS, and GENOTOXIC STRESS such as ionizing ultraviolet A light, thereby acting as a DNA damage sensor. These proteins play a role in a wide range of signaling mechanisms in cell cycle control.
Preferred term Ataxia Telangiectasia Mutated Proteins
Entry term(s) A T Protein
A-T Protein
AT Mutated Protein
ATM Protein
Mutated Protein, AT
Protein, A-T
Protein, AT Mutated



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