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Descriptor English: Thrombospondins
Descriptor Spanish: Trombospondinas
Descriptor trombospondinas
Scope note: Familia de glicoproteínas de adhesión relacionadas que se sintetizan, segregan, e incorporan a la matriz extracelular de una variedad de células, incluidos los gránulos alfa de las plaquetas, trás la activación de la trombina y de las células endoteliales. Interactúan con un numeroso grupo de FACTORES DE LA COAGULACIÓN SANGUÍNEA y de factores anticoagulantes. Se han identificado cinco formas diferentes, trombospondina 1, -2, -3, -4, y matriz proteica oligomérica del cartílago (COMP). Intervienen en la adhesión celular, agregación plaquetaria, proliferación celular, angiogénesis, metástasis tumoral, crecimiento del MÚSCULO LISO VASCULAR, y en la reparación tisular.
Descriptor Portuguese: Trombospondinas
Descriptor French: Thrombospondines
Entry term(s): Thrombospondin
Tree number(s): D09.400.430.890.895
D12.776.395.550.895
D12.776.543.550.895
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019699
Scope note: A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.
Annotation: membrane glycoproteins; THROMBOSPONDIN 1 is also available
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Glycoproteins (1981-1989)
Membrane Glycoproteins (1989-1997)
Platelet Membrane Glycoproteins (1992-1993)
Public MeSH Note: 98; THROMBOSPONDIN was indexed under MEMBRANE GLYCOPROTEINS 1989-97, PLATELET MEMBRANE GLYCOPROTEINS 1992-93, & GLYCOPROTEINS 1981-89
History Note: 98; see THROMBOSPONDINS (NM) 1981-97
DeCS ID: 33492
Unique ID: D019699
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2008/07/08
Thrombospondins - Preferred
Concept UI M0029253
Scope note A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.
Preferred term Thrombospondins
Entry term(s) Thrombospondin



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