| Descriptor English: | AC133 Antigen | ||||||
| Descriptor Spanish: |
Antígeno AC133
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| Descriptor Portuguese: | Antígeno AC133 | ||||||
| Descriptor French: | Antigène AC133 | ||||||
| Entry term(s): |
AC133 1 Antigen AC133 2 Antigen AC133-1 Antigen AC133-2 Antigen AC141 Antigen Antigen, AC133 Antigen, AC133-1 Antigen, AC133-2 Antigen, AC141 Antigen, CD133 CD133 Antigen Fudenine PROML1 Prominin Prominin 1 Prominin Like PROML1 Prominin-1 Prominin-Like PROML1 |
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| Tree number(s): |
D09.400.430.890.007 D12.776.395.550.007 D12.776.543.550.023 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000071916 | ||||||
| Scope note: | A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring as several isoforms produced by alternative splicing which are processed into mature forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. Functionally, it is associated with roles in cell differentiation, proliferation, and apoptosis. Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Public MeSH Note: | 2017; AC133 ANTIGEN was indexed under GLYCOPROTEINS, PEPTIDES and ANTIGENS, CD 1998-2016 |
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| History Note: | 2017(1998) |
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| Related: |
Antigen-Antibody Reactions
MeSH | ||||||
| DeCS ID: | 56518 | ||||||
| Unique ID: | D000071916 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2017/01/01 | ||||||
| Date of Entry: | 2016/07/08 | ||||||
| Revision Date: | 2017/05/24 |
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CHEMICALS AND DRUGS
Carbohydrates [D09]Carbohydrates -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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AC133 Antigen
- Preferred
AC141 Antigen
- Narrower
AC133-2 Antigen
- Narrower
| Concept UI |
M0288458 |
| Scope note | A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring as several isoforms produced by alternative splicing which are processed into mature forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. Functionally, it is associated with roles in cell differentiation, proliferation, and apoptosis. Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism. |
| Preferred term | AC133 Antigen |
| Entry term(s) |
AC133 1 Antigen AC133-1 Antigen Antigen, AC133 Antigen, AC133-1 Antigen, CD133 CD133 Antigen Fudenine PROML1 Prominin Prominin 1 Prominin Like PROML1 Prominin-1 Prominin-Like PROML1 |
| Concept UI |
M000617722 |
| Preferred term | AC141 Antigen |
| Entry term(s) |
Antigen, AC141 |
| Concept UI |
M000617723 |
| Preferred term | AC133-2 Antigen |
| Entry term(s) |
AC133 2 Antigen Antigen, AC133-2 |
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