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Descriptor English: Discoidin Domain Receptors
Descriptor Spanish: Receptores con Dominio Discoidina
Descriptor receptores con dominio discoidina
Entry term(s) proteínas DDR
receptor con dominio discoidina
Scope note: Receptores tirosina quinasa que unen COLÁGENOS. Se caracterizan por la presencia de DOMINIOS DISCOIDINA extracelulares que activan las VÍAS DE TRANSDUCCIÓN DE SEÑAL en respuesta a la unión de colágeno. También pueden ser escindidos por METALOPROTEINASAS DE LA MATRIZ mediando entonces las interacciones con la MATRIZ EXTRACELULAR.
Descriptor Portuguese: Receptores com Domínio Discoidina
Descriptor French: Récepteurs à domaine discoïdine
Entry term(s): DDR Proteins
Discoidin Domain Receptor
Proteins, DDR
Receptor, Discoidin Domain
Receptors, Discoidin Domain
Tree number(s): D08.811.913.696.620.682.725.400.005
D12.776.476.568.400.005
D12.776.543.750.630.005
D12.776.543.750.685.050
D12.776.543.750.705.880.300
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000070818
Scope note: Receptor tyrosine kinases that bind COLLAGENS. They are characterized by the presence of extracellular DISCOIDIN DOMAINS that activate SIGNAL TRANSDUCTION PATHWAYS in response to collagen binding. They may also be cleaved by MATRIX METALLOPROTEINASES to mediate cell interactions with the EXTRACELLULAR MATRIX.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Registry Number: EC 2.7.10.1
Public MeSH Note: 2017; DISCOIDIN DOMAIN RECEPTORS was indexed under RECEPTORS, MITOGEN and RECEPTOR PROTEIN-TYROSINE KINASES 1999-2016
History Note: 2017 (1999)
DeCS ID: 56514
Unique ID: D000070818
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/01/15
Discoidin Domain Receptors - Preferred
Concept UI M0134195
Scope note Receptor tyrosine kinases that bind COLLAGENS. They are characterized by the presence of extracellular DISCOIDIN DOMAINS that activate SIGNAL TRANSDUCTION PATHWAYS in response to collagen binding. They may also be cleaved by MATRIX METALLOPROTEINASES to mediate cell interactions with the EXTRACELLULAR MATRIX.
Preferred term Discoidin Domain Receptors
Entry term(s) DDR Proteins
Discoidin Domain Receptor
Proteins, DDR
Receptor, Discoidin Domain
Receptors, Discoidin Domain



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