| Descriptor English: | Pre-B-Cell Leukemia Transcription Factor 1 | ||||||
| Descriptor Spanish: |
Factor de Transcripción 1 de la Leucemia de Células Pre-B
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| Descriptor Portuguese: | Fator de Transcrição 1 de Leucemia de Células Pré-B | ||||||
| Descriptor French: | Facteur de transcription-1 de la leucémie pré-B | ||||||
| Entry term(s): |
Homeobox Protein, PBX1 PBX1 Homeobox Protein Pre B Cell Leukemia Homeobox 1 Protein Pre B Cell Leukemia Transcription Factor 1 Pre-B-Cell Leukemia Homeobox 1 Protein |
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| Tree number(s): |
D12.776.260.400.836 D12.776.624.664.700.163 D12.776.930.712 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000075062 | ||||||
| Scope note: | A TALE-type homeodomain protein and transcription factor that binds the DNA sequence 5'-ATCAATCAA-3'. It forms a heterodimer with MEIS1 TRANSCRIPTION FACTOR and functions as a transcriptional activator of HOMEOBOX PROTEIN NKX-2.5 and ELONGIN A, and as a transcriptional repressor of CDKN2B PROTEIN, in the regulation of developmental and morphogenetic processes such as spleen and limb development. Chromosome translocations involving the PBX1 and TCF3 genes occur in cases of pre-B-cell ACUTE LYMPHOID LEUKEMIA. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
DNA-Binding Proteins (1993-2017) Proto-Oncogene Proteins (1993-2017) |
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| Public MeSH Note: | 2018 |
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| History Note: | 2018 |
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| DeCS ID: | 57110 | ||||||
| Unique ID: | D000075062 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/05/22 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Pre-B-Cell Leukemia Transcription Factor 1
- Preferred
| Concept UI |
M000629051 |
| Scope note | A TALE-type homeodomain protein and transcription factor that binds the DNA sequence 5'-ATCAATCAA-3'. It forms a heterodimer with MEIS1 TRANSCRIPTION FACTOR and functions as a transcriptional activator of HOMEOBOX PROTEIN NKX-2.5 and ELONGIN A, and as a transcriptional repressor of CDKN2B PROTEIN, in the regulation of developmental and morphogenetic processes such as spleen and limb development. Chromosome translocations involving the PBX1 and TCF3 genes occur in cases of pre-B-cell ACUTE LYMPHOID LEUKEMIA. |
| Preferred term | Pre-B-Cell Leukemia Transcription Factor 1 |
| Entry term(s) |
Homeobox Protein, PBX1 PBX1 Homeobox Protein Pre B Cell Leukemia Homeobox 1 Protein Pre B Cell Leukemia Transcription Factor 1 Pre-B-Cell Leukemia Homeobox 1 Protein |
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