| Descriptor English: | Asialoglycoproteins | ||||||
| Descriptor Spanish: |
Asialoglicoproteínas
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| Descriptor Portuguese: | Assialoglicoproteínas | ||||||
| Descriptor French: | Asialoglycoprotéines | ||||||
| Entry term(s): |
Asialoglycoprotein Desialylated Glycoproteins Glycoproteins, Desialylated |
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| Tree number(s): |
D12.776.395.140 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D001212 | ||||||
| Scope note: | Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Glycoproteins (1966-1984) |
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| Public MeSH Note: | 85 |
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| History Note: | 85 |
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| Related: |
Asialoglycoprotein Receptor
MeSH | ||||||
| DeCS ID: | 1219 | ||||||
| Unique ID: | D001212 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1985/01/01 | ||||||
| Date of Entry: | 1984/05/30 | ||||||
| Revision Date: | 2005/07/13 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Asialoglycoproteins
- Preferred
| Concept UI |
M0001810 |
| Scope note | Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS. |
| Preferred term | Asialoglycoproteins |
| Entry term(s) |
Asialoglycoprotein Desialylated Glycoproteins Glycoproteins, Desialylated |
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