DeCS

Descriptor English:

Histocompatibility Antigens Class I

Descriptor Spanish:

Antígenos de Histocompatibilidad Clase I

Spanish from Spain

Descriptor	antígenos de histocompatibilidad de clase I
Entry term(s)	antígeno de clase I antígeno de histocompatibilidad de clase I antígeno del complejo principal de histocompatibilidad de clase I antígenos de clase I molécula del MHC de clase I moléculas MHC I moléculas de clase I del MHC moléculas de clase I del complejo principal de histocompatibilidad proteína del MHC de clase I proteínas de clase I del MHC péptido del MHC-I péptidos MHC I péptidos MHC de clase I
Scope note:	Glicoproteínas membranarias que constan de una subunidad alfa y una subunidad beta de MICROGLOBULINA BETA 2. En los humanos, genes muy polimórficos en el CROMOSOMA 6 codifican las subunidades alfa de los antígenos de clase I y desempeñan un importante papel en la determinación de la especificidad serológica del antígeno de superficie. Los antígenos de clase I se encuentran en la mayoría de las células nucleadas y se detectan generalmente por su reactividad con aloantisueros. Estos antígenos son reconocidos durante el RECHAZO DE TRASPLANTES y restringen la lisis de mediación celular de las células infectadas por virus.

Descriptor Portuguese:

Antígenos de Histocompatibilidade Classe I

Descriptor French:

Antigènes d'histocompatibilité de classe I

Entry term(s):

Antigen, Class I
Antigens, Class I
Class I Antigen
Class I Antigens
Class I Histocompatibility Antigen
Class I Histocompatibility Antigens
Class I Human Antigens
Class I MHC Protein
Class I MHC Proteins
Class I Major Histocompatibility Antigen
Class I Major Histocompatibility Antigens
Class I Major Histocompatibility Molecules
Human Class I Antigens
I Antigen, Class
MHC Class I Molecule
MHC Class I Molecules
MHC I Molecules
MHC I Peptide
MHC I Peptides
MHC-I Molecules
MHC-I Peptide
MHC-I Peptides
Molecules, MHC-I
Peptide, MHC-I
Peptides, MHC-I

Tree number(s):

D09.400.430.890.489
D12.776.395.550.489
D12.776.543.550.439
D23.050.301.500.100
D23.050.705.552.100

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D015395

Scope note:

Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.

Annotation:

human & animal

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Concept UI	M0023721
Scope note	Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Preferred term	Histocompatibility Antigens Class I
Entry term(s)	Antigen, Class I Antigens, Class I Class I Antigen Class I Antigens Class I Histocompatibility Antigen Class I Histocompatibility Antigens Class I MHC Protein Class I MHC Proteins Class I Major Histocompatibility Antigen Class I Major Histocompatibility Antigens Class I Major Histocompatibility Molecules I Antigen, Class MHC Class I Molecule MHC Class I Molecules MHC I Molecules MHC I Peptide MHC I Peptides MHC-I Molecules MHC-I Peptide MHC-I Peptides Molecules, MHC-I Peptide, MHC-I Peptides, MHC-I

Concept UI	M0023720
Preferred term	Human Class I Antigens
Entry term(s)	Class I Human Antigens

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