| Descriptor English: | DNA Topoisomerases, Type I | ||||||
| Descriptor Spanish: |
ADN-Topoisomerasas de Tipo I
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| Descriptor Portuguese: | DNA Topoisomerases Tipo I | ||||||
| Descriptor French: | ADN topoisomérases de type I | ||||||
| Entry term(s): |
DNA Nicking-Closing Protein DNA Nicking-Closing Proteins DNA Relaxing Enzyme DNA Relaxing Enzymes DNA Relaxing Protein DNA Topoisomerase DNA Topoisomerase I DNA Topoisomerase III DNA Topoisomerase III alpha DNA Topoisomerase III beta DNA Type 1 Topoisomerase DNA Untwisting Enzyme DNA Untwisting Enzymes DNA Untwisting Protein DNA Untwisting Proteins III beta, Topoisomerase III, DNA Topoisomerase III, Topo III, Topoisomerase IIIalpha, TOPO IIIalpha, Topoisomerase IIIbeta, Topoisomerase TOP3 Topoisomerase TOP3alpha TOPO IIIalpha Topo III Topoisomerase I Topoisomerase III Topoisomerase III beta Topoisomerase III, DNA Topoisomerase IIIalpha Topoisomerase IIIbeta Topoisomerase, TOP3 Type I DNA Topoisomerase beta, Topoisomerase III |
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| Tree number(s): |
D08.811.399.403.483 D12.776.157.687.375 D12.776.660.720.375 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D004264 | ||||||
| Scope note: | DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix. |
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| Annotation: | do not confuse entry term DNA UNTWISTING PROTEIN with DNA UNWINDING PROTEINS see DNA HELICASES; coordinate with BACTERIAL PROTEINS or ARCHAEAL PROTEINS if pertinent |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Entry Combination: |
antagonists & inhibitors:Topoisomerase I Inhibitors
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| Registry Number: | EC 5.99.1.2 | ||||||
| CAS Type 1 Name: | DNA topoisomerase | ||||||
| Previous Indexing: |
DNA, Circular (1973-1977) Deoxyribonucleases (1966-1977) Polynucleotide Synthetases (1973-1977) Proteins (1966-1977) specific protein (1966-1977) |
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| Public MeSH Note: | 2002; see DNA TOPOISOMERASE 1994-2001, see DNA UNTWISTING PROTEINS 1978-1993; for DNA NICKING-CLOSING PROTEIN see DNA NICKING-CLOSING PROTEINS 1978-1993; for DNA RELAXING ENZYME see DNA RELAXING ENZYMES 1978-1993; for DNA UNTWISTING ENZYME see DNA UNTWISTING ENZYMES 1978-1993 |
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| History Note: | 2002 |
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| DeCS ID: | 31732 | ||||||
| Unique ID: | D004264 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1978/01/01 | ||||||
| Date of Entry: | 1977/04/15 | ||||||
| Revision Date: | 2019/07/08 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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DNA Topoisomerases, Type I
- Preferred
DNA Topoisomerase III alpha
- Narrower
DNA Topoisomerase III beta
- Narrower
DNA Topoisomerase III
- Narrower
| Concept UI |
M0381011 |
| Scope note | DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix. |
| Preferred term | DNA Topoisomerases, Type I |
| Entry term(s) |
DNA Nicking-Closing Protein DNA Nicking-Closing Proteins DNA Relaxing Enzyme DNA Relaxing Enzymes DNA Relaxing Protein DNA Topoisomerase DNA Topoisomerase I DNA Type 1 Topoisomerase DNA Untwisting Enzyme DNA Untwisting Enzymes DNA Untwisting Protein DNA Untwisting Proteins Topoisomerase I Type I DNA Topoisomerase |
| Concept UI |
M000649950 |
| Preferred term | DNA Topoisomerase III alpha |
| Entry term(s) |
IIIalpha, TOPO IIIalpha, Topoisomerase TOP3alpha TOPO IIIalpha Topoisomerase IIIalpha |
| Concept UI |
M000649951 |
| Preferred term | DNA Topoisomerase III beta |
| Entry term(s) |
III beta, Topoisomerase IIIbeta, Topoisomerase Topoisomerase III beta Topoisomerase IIIbeta beta, Topoisomerase III |
| Concept UI |
M000649952 |
| Preferred term | DNA Topoisomerase III |
| Entry term(s) |
III, DNA Topoisomerase III, Topo III, Topoisomerase TOP3 Topoisomerase Topo III Topoisomerase III Topoisomerase III, DNA Topoisomerase, TOP3 |
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