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Descriptor English: Silent Information Regulator Proteins, Saccharomyces cerevisiae
Descriptor Spanish: Proteínas Reguladoras de Información Silente de Saccharomyces cerevisiae
Descriptor proteínas reguladoras de información silente de Saccharomyces cerevisiae
Entry term(s) proteínas SIR de S cerevisiae
Scope note: Conjunto de proteínas nucleares de SACCHAROMYCIES CEREVISIAE requeridas para la represión transcripcional de los locus silentes de tipo apareamiento. Median en la formación de CROMATINA silenciada y además reprimen la transcripción y la recombinación en otros locus. Están compuestas de 4 proteínas interactuantes no homólogas, Sir1p, Sir2p, Sir3p y Sir4p. La Sir2, HISTONA DESACETILASA NAD-dependiente, es el miembro fundador de la familia de SIRTUINAS.
Descriptor Portuguese: Proteínas Reguladoras de Informação Silenciosa de Saccharomyces cerevisiae
Descriptor French: Protéines SIR de Saccharomyces cerevisiae
Entry term(s): SIR Proteins, S cerevisiae
Silent Information Regulator Proteins, S cerevisiae
Silent Mating Type Information Regulator Protein, S cerevisiae
Tree number(s): D12.776.354.750.750
D12.776.660.820
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D038281
Scope note: A set of nuclear proteins in SACCHAROMYCES CEREVISIAE that are required for the transcriptional repression of the silent mating type loci. They mediate the formation of silenced CHROMATIN and repress both transcription and recombination at other loci as well. They are comprised of 4 non-homologous, interacting proteins, Sir1p, Sir2p, Sir3p, and Sir4p. Sir2p, an NAD-dependent HISTONE DEACETYLASE, is the founding member of the family of SIRTUINS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2003
History Note: 2003
Entry Version: SILENT INFORMATION REGULAT PROTEINS SACCH CEREV
Related: Sirtuins MeSH
DeCS ID: 37446
Unique ID: D038281
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2005/06/30
Silent Information Regulator Proteins, Saccharomyces cerevisiae - Preferred
Concept UI M0415710
Scope note A set of nuclear proteins in SACCHAROMYCES CEREVISIAE that are required for the transcriptional repression of the silent mating type loci. They mediate the formation of silenced CHROMATIN and repress both transcription and recombination at other loci as well. They are comprised of 4 non-homologous, interacting proteins, Sir1p, Sir2p, Sir3p, and Sir4p. Sir2p, an NAD-dependent HISTONE DEACETYLASE, is the founding member of the family of SIRTUINS.
Preferred term Silent Information Regulator Proteins, Saccharomyces cerevisiae
Entry term(s) SIR Proteins, S cerevisiae
Silent Information Regulator Proteins, S cerevisiae
Silent Mating Type Information Regulator Protein, S cerevisiae - Narrower
Concept UI M0415711
Preferred term Silent Mating Type Information Regulator Protein, S cerevisiae



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