| Descriptor English: | Fanconi Anemia Complementation Group N Protein | ||||||
| Descriptor Spanish: |
Proteína del Grupo de Complementación N de la Anemia de Fanconi
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| Descriptor Portuguese: | Proteína do Grupo de Complementação N da Anemia de Fanconi | ||||||
| Descriptor French: | Protéine du groupe de complémentation N de l'anémie de Fanconi | ||||||
| Entry term(s): |
FANCN Protein PALB2 Protein Partner and Localizer of BRCA2 Protein |
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| Tree number(s): |
D12.776.313.953 D12.776.624.776.051 D12.776.660.323 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000076164 | ||||||
| Scope note: | A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Nuclear Proteins (2006-2017) Tumor Suppressor Proteins (2006-2017) |
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| Public MeSH Note: | 2018 |
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| History Note: | 2018 |
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| DeCS ID: | 57122 | ||||||
| Unique ID: | D000076164 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/06/29 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Fanconi Anemia Complementation Group N Protein
- Preferred
| Concept UI |
M000632389 |
| Scope note | A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER. |
| Preferred term | Fanconi Anemia Complementation Group N Protein |
| Entry term(s) |
FANCN Protein PALB2 Protein Partner and Localizer of BRCA2 Protein |
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